Changes in rat myocardium contractility under subchronic intoxication with lead and cadmium salts administered alone or in combination

被引：15

作者：

Protsenko, Yuri L. ^{[1
]}

Klinova, Svetlana V. ^{[2
]}

Gerzen, Oksana P. ^{[1
]}

Privalova, Larisa I. ^{[2
]}

Minigalieva, Ilzira A. ^{[2
]}

Balakin, Alexander A. ^{[1
]}

Lookin, Oleg N. ^{[1
,3
]}

Lisin, Ruslan V. ^{[1
]}

Butova, Ksenya A. ^{[1
]}

Nabiev, Salavat R. ^{[1
]}

Katsnelson, Leonid B. ^{[1
,3
]}

Nikitina, Larisa V. ^{[1
]}

Katsnelson, Boris A. ^{[2
]}

机构：

[1] Russian Acad Sci, Ural Branch, Inst Immunol & Physiol, Ekaterinburg, Russia

[2] Yekaterinburg Med Res Ctr Prophylaxis & Hlth Prot, Ekaterinburg, Russia

[3] Ural Fed Univ, Ekaterinburg, Russia

来源：

TOXICOLOGY REPORTS | 2020年 / 7卷

关键词：

Cardiotoxicity; Lead; Cadmium; Myocardium contractility; Myosin; Trabecules; Papillary muscles; Bioprotectors; CARDIAC-MUSCLE; BLOOD-PRESSURE; HEART-MUSCLE; EXPOSURE; PHOSPHORYLATION; ACTIVATION; TENSION; PROTEIN; TITIN; RISK;

D O I：

10.1016/j.toxrep.2020.03.001

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Subchronic intoxications induced in male rats by repeated intraperitoneal injections of lead acetate and cadmium chloride, administered either alone or in combination, are shown to affect the biochemical, cytological and morphometric parameters of blood, liver, heart and kidneys. The single twitch parameters of myocardial trabecular and papillary muscle preparations were measured in the isometric regime to identify changes in the heterometric (length-force) and chronoinotropic (frequency-force) contractility regulation systems. Differences in the responses of these systems in trabecules and papillary muscles to the above intoxications are shown. A number of myocardium mechanical characteristics changing in rats under the effect of a combined lead-cadmium intoxication and increased proportion of alpha-myosin heavy chains were observed to normalize fully or partially if such intoxication was induced against background administration of a proposed bioprotective complex. Based on the experimental results and literature data, some assumptions are suggested concerning the mechanisms of the cardiotoxic effects produced by lead and cadmium.

引用

页码：433 / 442

页数：10

共 5 条

[1] Rat myocardium contractility changes associated with a subchronic lead intoxication
Klinova, S.
Katsnelson, B.
Protsenko, Y.
Lookin, O.
Balakin, A.
Nikitina, L.
Gerzen, O.
Nabiev, S.
Minigalieva, I.
Privalova, L.
Katsnelson, L.
TOXICOLOGY LETTERS, 2019, 314 : S277 - S278
[2] Further analysis of rat myocardium contractility changes associated with a subchronic lead intoxication
Protsenko, Yuri L.
Katsnelson, Boris A.
Klinova, Svetlana V.
Lookin, Oleg N.
Balakin, Alexander A.
Nikitina, Larisa V.
Gerzen, Oksana P.
Nabiev, Salavat R.
Minigalieva, Ilzira A.
Privalova, Larisa I.
Gurvich, Vladimir B.
Sutunkova, Marina P.
Katsnelson, Leonid B.
FOOD AND CHEMICAL TOXICOLOGY, 2019, 125 : 233 - 241
[3] Effects of subchronic lead intoxication of rats on the myocardium contractility
Protsenko, Yuri L.
Katsnelson, Boris A.
Klinova, Svetlana V.
Lookin, Oleg N.
Balakin, Alexander A.
Nikitina, Larisa V.
Gerzen, Oksana P.
Minigalieva, Ilzira A.
Privalova, Larisa I.
Gurvich, Vladimir B.
Sutunkova, Marina P.
Katsnelson, Leonid B.
FOOD AND CHEMICAL TOXICOLOGY, 2018, 120 : 378 - 389
[4] Molecular mechanisms of mechanical function changes of the rat myocardium under subchronic lead exposure
Gerzen, Oksana P.
Nabiev, Salavat R.
Klinova, Svetlana V.
Minigalieva, Ilzira A.
Sutunkova, Marina P.
Katsnelson, Boris A.
V. Nikitina, Larisa
FOOD AND CHEMICAL TOXICOLOGY, 2022, 169
[5] Force-velocity characteristics of isolated myocardium preparations from rats exposed to subchronic intoxication with lead and cadmium acting separately or in combination
Katsnelson, Boris A.
Klinova, Svetlana, V
Gerzen, Oksana P.
Balakin, Alexander A.
Lookin, Oleg N.
Lisin, Ruslan, V
Nabiev, Salavat R.
Privalova, Larisa, I
Minigalieva, Ilzira A.
Panov, Vladimir G.
Katsnelson, Leonid B.
Nikitina, Larisa, V
Kuznetsov, Daniil A.
Protsenko, Yuri L.
FOOD AND CHEMICAL TOXICOLOGY, 2020, 144

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