Molecular mechanisms of mechanical function changes of the rat myocardium under subchronic lead exposure

被引：6
|
作者：
Gerzen, Oksana P. [1 ,3 ]
Nabiev, Salavat R. [1 ]
Klinova, Svetlana V. [2 ]
Minigalieva, Ilzira A. [2 ]
Sutunkova, Marina P. [2 ]
Katsnelson, Boris A. [2 ]
V. Nikitina, Larisa [1 ]
机构：
[1] Russian Acad Sci, Inst Immunol & Physiol Ural Branch, Ekaterinburg, Russia
[2] Yekaterinburg Med Res Ctr Prophylaxis & Hlth Prote, Ekaterinburg, Russia
[3] 106 Pervomayskaia str, Ekaterinburg 620049, Russia
来源：
FOOD AND CHEMICAL TOXICOLOGY | 2022年 / 169卷
关键词：
Lead exposure; Myocardium contractility; Heart chambers; Myosin; CARDIAC MYOSIN; CHAIN ISOFORMS; BLOOD-PRESSURE; THIN FILAMENT; CONTRACTILITY; TROPONIN; INTOXICATION; ACTIVATION; PROTEINS; CALCIUM;
D O I：
10.1016/j.fct.2022.113444
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
A moderate degree of lead intoxication was observed in male rats after repeated intraperitoneal injections with two doses of lead acetate three times a week during 5 (12.5 mg of Pb per kg body mass) and 6 (6.01 mg of Pb per kg body mass) weeks. Using an in vitro motility assay, we investigated the impact of this intoxication on the characteristics of actin-myosin interaction and its regulation in the atria, right, and left ventricles. Both lead doses exposure decreased the maximum sliding velocity of reconstituted thin filaments over myosin and fraction of motile filaments in all heart chambers, caused the myosin isoforms shift towards slower beta-myosin heavy chains in ventricles and decreased regulatory light chain phosphorylation in atria. No statistically significant difference was found in force and calcium regulation of actin-myosin interaction. A dose-dependent effect of lead on myosin functional characteristics was found in all heart chambers, but the degree of this effect varied depending on the heart chamber.
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页数：10
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