Modelling the influence of thalamo-cortical projections on prefrontal activity

被引：0

作者：

Kamper, L

Bozkurt, A

Nielsen, P

Dyhrfjeld-Johnsen, J

Stephan, KE

Kötter, R ^{[1
]}

机构：

[1] Univ Dusseldorf, C & O Vogt Brain Res Inst, Computat Syst Neurosci Grp, D-40225 Dusseldorf, Germany

[2] Univ Copenhagen, Niels Bohr Inst Astrophys Phys & Geophys, Copenhagen, Denmark

[3] Univ Newcastle Upon Tyne, Dept Psychol, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[4] Univ Dusseldorf, Inst Morphol Endocrinol & Histochem, D-40225 Dusseldorf, Germany

来源：

NEUROCOMPUTING | 2002年 / 44卷

关键词：

schizophrenia; thalamus; prefrontal cortex; connectivity; computer model;

D O I：

10.1016/S0925-2312(02)00485-X

中图分类号：

TP18 [人工智能理论];

学科分类号：

081104 ; 0812 ; 0835 ; 1405 ;

摘要：

Altered connections between the thalamus and the prefrontal cortex are often implicated in theories concerning the pathogenesis of schizophrenia. Using a model based on anatomically realistic connection patterns between thalamus and prefrontal cortex, we analyzed changes of prefrontal activity resulting from stimulation of the mediodorsal thalamus. Here we demonstrate that the specific influence of thalamo-cortical projections is smaller than the importance of intra-prefrontal connectivity in shaping prefrontal activity patterns. These results might be helpful in explaining experimentally observed hypo- and hyperactive states of prefrontal cortex in schizophrenic patients, (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：869 / 873

页数：5

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