Titanium Binolate Catalyzed Aminolysis of meso Aziridines: A Highly Enantioselective and Direct Access to 1,2-Diamines

被引：46

作者：

Peruncheralathan, Saravanan ^{[1
]}

Teller, Henrik ^{[1
]}

Schneider, Christoph ^{[1
]}

机构：

[1] Univ Leipzig, Inst Organ Chem, D-4103 Leipzig, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 26期

关键词：

asymmetric catalysis; aziridines; desymmetrization; 1,2-diamines; titanium; GLYOXYLATE ENE REACTION; ALPHA-HYDROXY ESTERS; ASYMMETRIC ALLYLATION; PRACTICAL ACCESS; ALKYL-GROUPS; ALDEHYDES; DESYMMETRIZATION; COMPLEXES; DIETHYLZINC; MECHANISM;

D O I：

10.1002/anie.200901110

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

It's as simple as that: An in situ prepared chiral catalyst from the commercially available compounds Ti(OiPr)4 and (R)-binol catalyzes the highly enantioselective ring-opening of meso-aziridines 1 with anilines 2 and furnishes valuable chiral 1,2-diamines 3 in high yields and up to 99 % ee.(R)- binol=(R)-2,2′-dihydroxy-1,1′-binaphthyl. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4849 / 4852

页数：4

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