Vascular stiffening and endothelial dysfunction in atherosclerosis

被引：22

作者：

Hooglugt, Aukie ^{[1
,2
]}

Klatt, Olivia ^{[1
]}

Huveneers, Stephan ^{[1
,3
]}

机构：

[1] Univ Amsterdam, Amsterdam UMC, Dept Med Biochem, Amsterdam Cardiovasc Sci, Amsterdam, Netherlands

[2] Vrije Univ Amsterdam Med Ctr, Amsterdam UMC, Amsterdam Cardiovasc Sci, Dept Physiol, Amsterdam, Netherlands

[3] Univ Amsterdam, Amsterdam UMC, Dept Med Biochem, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands

来源：

CURRENT OPINION IN LIPIDOLOGY | 2022年 / 33卷 / 06期

关键词：

Aging; atherosclerosis; endothelium; mechanotransduction; stiffness; PULSE-WAVE VELOCITY; ARTERIAL STIFFNESS; EXTRACELLULAR-MATRIX; ATOMIC-FORCE; SYSTOLIC HYPERTENSION; SUBENDOTHELIAL MATRIX; CARDIOVASCULAR RISK; SHEAR-STRESS; YAP/TAZ; TISSUE;

D O I：

10.1097/MOL.0000000000000852

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Purpose of reviewAging is an important risk factor for cardiovascular disease and is associated with increased vessel wall stiffness. Pathophysiological stiffening, notably in arteries, disturbs the integrity of the vascular endothelium and promotes permeability and transmigration of immune cells, thereby driving the development of atherosclerosis and related vascular diseases. Effective therapeutic strategies for arterial stiffening are still lacking.Recent findingsHere, we overview the literature on age-related arterial stiffening, from patient-derived data to preclinical in-vivo and in-vitro findings. First, we overview the common techniques that are used to measure stiffness and discuss the observed stiffness values in atherosclerosis and aging. Next, the endothelial response to stiffening and possibilities to attenuate this response are discussed.Future research that will define the endothelial contribution to stiffness-related cardiovascular disease may provide new targets for intervention to restore endothelial function in atherosclerosis and complement the use of currently applied lipid-lowering, antihypertensive, and anti-inflammatory drugs.

引用

页码：353 / 363

页数：11

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