Copper-Catalyzed Reductive Cross-Coupling of Nonactivated Alkyl Tosylates and Mesylates with Alkyl and Aryl Bromides

被引：86

作者：

Liu, Jing-Hui ^{[1
,2
,3
]}

Yang, Chu-Ting ^{[1
]}

Lu, Xiao-Yu ^{[1
]}

Zhang, Zhen-Qi ^{[1
]}

Xu, Ling ^{[1
]}

Cui, Mian ^{[1
]}

Lu, Xi ^{[1
]}

Xiao, Bin ^{[1
]}

Fu, Yao ^{[1
]}

Liu, Lei ^{[1
,2
,3
]}

机构：

[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China

[2] Chinese Acad Sci, State Key Lab Oxo Synth & Select Oxidat, Lanzhou Inst Chem Phys, Lanzhou 730000, Peoples R China

[3] Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2014年 / 20卷 / 47期

关键词：

catalysis; C-C bond formation; copper; cross-coupling; cyclization; GRIGNARD-REAGENTS; ALLYLIC ACETATES; HALIDES; COBALT; SECONDARY; IODIDES; NI; PD;

D O I：

10.1002/chem.201405223

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A copper-catalyzed reductive cross-coupling reaction of nonactivated alkyl tosylates and mesylates with alkyl and aryl bromides was developed. It provides a practical method for efficient and cost-effective construction of aryl-alkyl and alkyl-alkyl C-C bonds with stereocontrol from readily available substrates. When used in an intramolecular fashion, the reaction enables convenient access to various substituted carbo-or heterocycles, such as 2,3-dihydrobenzofuran and benzochromene derivatives.

引用

页码：15334 / 15338

页数：5

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