Dimethyl fumarate: targeting glycolysis to treat MS

被引：20
|
作者：
Angiari, Stefano [1 ]
O'Neill, Luke A. [1 ]
机构：
[1] Trinity Coll Dublin, Sch Biochem & Immunol, Trinity Biomed Sci Inst, Dublin 2, Ireland
来源：
CELL RESEARCH | 2018年 / 28卷 / 06期
基金：
英国惠康基金;
关键词：
D O I：
10.1038/s41422-018-0045-3
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Dimethyl fumarate (DMF) is an immunomodulatory drug used in patients with multiple sclerosis (MS) and psoriasis. Kornberg and colleagues shed new light on DMF activity, demonstrating that it blocks immune cell activation through inhibition of glycolysis via post-transcriptional modification of glyceraldehyde 3-phosphate dehydrogenase (GAPDH), which confirms the pro-inflammatory role of glycolysis and points to potential new targets to treat inflammatory diseases such as MS.
引用
收藏
页码：613 / 615
页数：3
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