Greasing the gears of potassium channels

被引：4
|
作者：
Swartz, Kenton J. [1 ]
机构：
[1] NINDS, Mol Physiol & Biophys Sect, NIH, Bethesda, MD 20892 USA
[2] NINDS, Porter Neurosci Res Ctr, NIH, Bethesda, MD 20892 USA
来源：
NATURE CHEMICAL BIOLOGY | 2006年 / 2卷 / 08期
关键词：
D O I：
10.1038/nchembio0806-401
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Enzymatic conversion of sphingomyelin to ceramide-1-phosphate in the external leaflet of the cellular membrane has now been shown to markedly facilitate opening of classical voltage-activated potassium channels. This discovery raises the possibility that lipids may have more prominent roles in the gating mechanism of these important ion channels than was previously appreciated.
引用
收藏
页码：401 / 402
页数：3
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