Prostate cancer vaccines in combination with additional treatment modalities

被引：15
|
作者：
Uhlman, Matthew A. [1 ]
Bing, Megan T. [1 ]
Lubaroff, David M. [1 ,2 ,3 ]
机构：
[1] Univ Iowa, Dept Urol, Iowa City, IA 52242 USA
[2] Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USA
[3] Univ Iowa, Holden Comprehens Canc Ctr, Iowa City, IA 52242 USA
来源：
IMMUNOLOGIC RESEARCH | 2014年 / 59卷 / 1-3期
关键词：
Prostate cancer; Immunotherapy; Cancer vaccines; Combination therapy; AUTOLOGOUS CELLULAR IMMUNOTHERAPY; SIPULEUCEL-T; IMMUNOSTIMULATORY PROPERTIES; ANTITUMOR-ACTIVITY; INCREASED SURVIVAL; RADIATION-THERAPY; ACID-PHOSPHATASE; DOUBLE-BLIND; PHASE-II; DOCETAXEL;
D O I：
10.1007/s12026-014-8532-1
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Immunotherapy has been investigated in both preclinical studies and clinical trials as a new therapy for prostate cancer. Vaccines, including those that utilize dendritic cells, viruses, or DNA, immunize against prostate-specific antigen and prostatic acid phosphatase. The vaccines have long been studied as monotherapy for the cancer, but increasingly more trials have been initiated in combination with other modalities. These include radiation, chemotherapy, and androgen deprivation therapy. This review describes and discusses the various combinations of vaccine immunotherapies.
引用
收藏
页码：236 / 242
页数：7
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