The quest for spatio-temporal control of CAR T cells

被引：13

作者：

Sun, Jie ^{[1
,2
]}

Sadelain, Michel ^{[1
,2
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Ctr Cell Engn, New York, NY 10065 USA

[2] Sloan Kettering Inst, Immunol Program, New York, NY 10065 USA

来源：

CELL RESEARCH | 2015年 / 25卷 / 12期

关键词：

D O I：

10.1038/cr.2015.131

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Chimeric antigen receptors (CARs) are synthetic receptors capable of directing potent antigen-specific anti-tumor T cell responses. A recent report by Wu et al. extends a series of strategies aiming to curb excessive T cell activity, utilizing in this instance a chemical dimerizer to aggregate antigen-binding, T cell-activating and costimulatory domains. © 2015 IBCB, SIBS, CAS.

引用

页码：1281 / 1282

页数：2

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