Cerebral rituximab uptake in multiple sclerosis: A 89Zr-immunoPET pilot study

被引：18

作者：

Hagens, Marloes H. J. ^{[1
,2
]}

Killestein, Joep ^{[1
,2
]}

Yaqub, Maqsood M. ^{[3
]}

van Dongen, Guus A. M. S. ^{[3
]}

Lammertsma, Adriaan A. ^{[3
]}

Barkhof, Frederik ^{[2
,3
]}

van Berckel, Bart N. M. ^{[2
,3
]}

机构：

[1] Vrije Univ Amsterdam Med Ctr, Dept Neurol, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands

[2] Vrije Univ Amsterdam Med Ctr, MS Ctr Amsterdam, Amsterdam, Netherlands

[3] Vrije Univ Amsterdam Med Ctr, Dept Radiol & Nucl Med, Amsterdam, Netherlands

来源：

MULTIPLE SCLEROSIS JOURNAL | 2018年 / 24卷 / 04期

关键词：

Multiple sclerosis; rituximab; monoclonal antibodies; B-lymphocytes; positron emission tomography; magnetic resonance imaging; IMMUNO-PET;

D O I：

10.1177/1352458517704507

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Previous studies have demonstrated that the chimeric monoclonal antibody rituximab significantly reduces clinical and radiological disease activity in relapsing-remitting multiple sclerosis as early as 4weeks after the first administration. The exact mechanisms leading to this rapid effect have not yet been clarified. The aim of this positron emission tomography study was to assess central nervous system penetration as a possible explanation, using zirconium-89-labelled rituximab. No evidence was found for cerebral penetration of [Zr-89]rituximab.

引用

页码：543 / 545

页数：3

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