The association between inherited thrombophilia and recurrent pregnancy loss in Turkish women

被引：0

作者：

Isaoglu, U. ^{[1
]}

Ulug, P. ^{[2
]}

Delibas, I. B. ^{[1
]}

Yilmaz, M. ^{[3
]}

Kumtepe, Y. ^{[3
]}

Dogan, H. ^{[4
]}

Tasdemir, S. ^{[5
]}

机构：

[1] Nenehatun Obstet & Gynecol Hosp, Erzurum, Turkey

[2] Erzincan Univ, Fac Med, Dept Obstet & Gynecol, Erzincan, Turkey

[3] Ataturk Univ, Fac Med, Dept Obstet & Gynecol, Erzurum, Turkey

[4] Ataturk Univ, Fac Med, Dept Med Biol, Erzurum, Turkey

[5] Ataturk Univ, Fac Med, Dept Med Genet, Erzurum, Turkey

来源：

CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY | 2014年 / 41卷 / 02期

关键词：

Recurrent pregnancy loss; Factor V Leiden; Prothrombin G20210A mutation; MTHFR C677T mutation; FACTOR-V-LEIDEN; PROTHROMBIN G20210A MUTATIONS; GENE-MUTATIONS; RISK-FACTORS; FETAL LOSS; COMMON; HYPERHOMOCYSTEINEMIA; POLYMORPHISMS; MISCARRIAGE; PREVALENCE;

D O I：

暂无

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To investigate the relation between recurrent pregnancy loss (RPL) and factor V Leiden, prothrombin G20210A, and C677T methylenetetrahydrofolate reductase (MTHFR) mutations. Materials and Methods: A case-control study was conducted on 95 consecutive cases with RPL, and 40 age-matched controls who had no history of pregnancy loss and had at least one successful pregnancy. After application of exclusion criteria, 60 patients in the study group and 40 control cases were compared for thrombophilic factors. Results: Thirteen out of 60 RPL cases and one out of 40 in the control group were carriers of factor V Leiden mutation. While six patients were carriers of prothrombin G20210A gene mutation, none in the control group carried this mutation. Twenty-nine out of 60 RPL cases and 17 out of 40 control cases had MTHFR mutation. Conclusion: The authors found a positive correlation between RPL and FVL and FII gene mutations, but no significant association between RPL and MTHFR gene mutation.

引用

页码：177 / 181

页数：5

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