High-Throughput Liquid-Liquid Extraction in 96-Well Format: Parallel Artificial Liquid Membrane Extraction

被引：0

作者：

Gjelstad, Astrid ^{[1
]}

Andresen, Alf Terje ^{[2
]}

Dahlgren, Anders ^{[3
]}

Gundersen, Thomas E. ^{[4
]}

Pedersen-Bjergaard, Stig ^{[1
,5
]}

机构：

[1] Univ Oslo, Sch Pharm, Oslo, Norway

[2] Vitas Analyt Serv Ltd, Oslo, Norway

[3] CTO Vitas, Oslo, Norway

[4] CRO Vitas Analyt Serv Ltd, Oslo, Norway

[5] Univ Copenhagen, Dept Pharm, Copenhagen, Denmark

来源：

LC GC NORTH AMERICA | 2017年 / 35卷 / 03期

关键词：

MICROEXTRACTION TECHNIQUES; SOLVENT-MICROEXTRACTION; ANALYTICAL-CHEMISTRY; HUMAN PLASMA;

D O I：

暂无

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Parallel artificial liquid membrane extraction (PALME) is a miniaturized version of liquid-liquid extraction (LLE) and is based on two 96-well plates in a sandwich-like configuration. With a very simple workflow, 96 samples can be processed simultaneously in PALME, providing analyte enrichment, highly efficient sample cleanup, and direct compatibility with liquid chromatography-mass spectrometry (LC-MS). The consumption of hazardous organic solvents is also almost eliminated using PALME as the sample preparation technique. This article summarizes current experiences with PALME, based on work both in a university laboratory and in an analytical services contract laboratory.

引用

页码：192 / 196

页数：5

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