An Improved Process for the Synthesis of 4H-Imidazo[1,5-a][1,4]benzodiazepines

被引：11

作者：

Yang, Jie ^{[1
]}

Teng, Yun ^{[1
]}

Ara, Shamim ^{[1
]}

Rallapalli, Sundari ^{[1
]}

Cook, James M. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Chem, Milwaukee, WI 53211 USA

来源：

SYNTHESIS-STUTTGART | 2009年 / 06期

关键词：

GABA(A)/Bz receptors; imidazo[1,5-a][1,4]benzodiazepines; ethyl isocyanoacetate; annulation; BENZODIAZEPINE; IMIDAZOBENZODIAZEPINES; PHARMACOPHORE; SUBSTITUENTS; SUBTYPES; LIGANDS; PROBES;

D O I：

10.1055/s-0028-1083358

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The construction of CNS active imidazo[1,5-a][1,4]benzodiazepines has been improved in a one-pot annulation process.

引用

页码：1036 / 1040

页数：5

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Daniele, Simona
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Mannelli, Lorenzo Di Cesare
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REDDY, PSN
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[J]. MAGNETIC RESONANCE IN CHEMISTRY, 1986, 24 (07) : 644 - 645
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