Characteristics and predictors of gastric cancer after Helicobacter pylori eradication

被引:41
|
作者
Shichijo, Satoki [1 ]
Hirata, Yoshihiro [2 ]
机构
[1] Osaka Int Canc Inst, Dept Gastrointestinal Oncol, Osaka 5418567, Japan
[2] Univ Tokyo, Inst Med Sci, Div Adv Genome Med, Tokyo 1088639, Japan
关键词
Gastric cancer; Eradication; Characteristic; Helicobacter pylori; Predictor; ENDOSCOPIC SUBMUCOSAL DISSECTION; INTESTINAL METAPLASIA; SERUM PEPSINOGEN; HIGH-RISK; KYOTO CLASSIFICATION; INFECTION; THERAPY; ASSOCIATION; RESECTION; ATROPHY;
D O I
10.3748/wjg.v24.i20.2163
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Helicobacter pylori (H. pylori) eradication can reduce gastric cancer. However, gastric cancer still develops after eradication, and cases who received eradication therapy are increasing. In this study, we have reviewed the characteristics and predictors of primary gastric cancer developing after H. pylori eradication. In terms of the characteristics, endoscopic, histologic, and molecular characteristics are reported. Endoscopically, gastric cancer after eradication is often depressedtype and shows a gastritis-like appearance, which sometimes makes the diagnosis difficult. Histologically, most gastric cancer after eradication is intestinal type, and non-neoplastic epithelium, also called epithelium with low-grade atypia, is frequently seen over the tumor, which is presumably the cause of the endoscopic gastritis-like appearance. As for molecular characteristics, some markers, such as Ki67, MUC2, and Wnt5a expression, are lower in cancer from patients in whom H. pylori has been eradicated. In terms of predictors, several Japanese studies have reported that severe endoscopic atrophy at eradication is a risk factor for gastric cancer development. Histologic intestinal metaplasia, especially in the corpus, and long-term use of proton pump inhibitors, are also reported as risk factors for gastric cancer after H. pylori eradication. These studies on the characteristics and predictors of gastric cancer development will become the cornerstone for establishing a novel surveillance program based on the gastric cancer risk stratification specific to H. pylori-eradicated patients.
引用
收藏
页码:2163 / 2172
页数:10
相关论文
共 50 条
  • [1] Characteristics and predictors of gastric cancer after Helicobacter pylori eradication
    Satoki Shichijo
    Yoshihiro Hirata
    [J]. World Journal of Gastroenterology, 2018, (20) : 2163 - 2172
  • [2] Clinicopathological Characteristics of Gastric Cancer after Helicobacter Pylori Eradication
    Miyake, Akio
    Yamanaka, Shoji
    Kenichi, Ohashi
    [J]. LABORATORY INVESTIGATION, 2019, 99
  • [3] Clinicopathological Characteristics of Gastric Cancer after Helicobacter Pylori Eradication
    Miyake, Akio
    Yamanaka, Shoji
    Kenichi, Ohashi
    [J]. MODERN PATHOLOGY, 2019, 32
  • [4] Clinicopathological characteristics of advanced gastric cancer after Helicobacter pylori eradication
    Tokura, Junki
    Namikawa, Ken
    Nakano, Kaoru
    Tokai, Yoshitaka
    Yoshimizu, Shoichi
    Horiuchi, Yusuke
    Ishiyama, Akiyoshi
    Yoshio, Toshiyuki
    Hirasawa, Toshiaki
    Nunobe, Souya
    Yamaguchi, Kensei
    Kawachi, Hiroshi
    Fujisaki, Junko
    [J]. JGH OPEN, 2022, 6 (12): : 833 - 838
  • [5] Gastric cancer detected after Helicobacter pylori eradication
    Tashiro, Jun
    Miwa, Jun
    Tomita, Takashige
    Matsubara, Yasuo
    Oota, Yasuhiko
    [J]. DIGESTIVE ENDOSCOPY, 2007, 19 (04) : 167 - 173
  • [6] Characteristics and Early Diagnosis of Gastric Cancer Discovered after Helicobacter pylori Eradication
    Ito, Masanori
    Tanaka, Shinji
    Chayama, Kazuaki
    [J]. GUT AND LIVER, 2021, 15 (03) : 338 - 345
  • [7] Metachronous gastric cancer after successful Helicobacter pylori eradication
    Shiotani, Akiko
    Haruma, Ken
    Graham, David Y.
    [J]. WORLD JOURNAL OF GASTROENTEROLOGY, 2014, 20 (33) : 11552 - 11559
  • [8] Clinicopathological Features of Gastric Cancer After Helicobacter Pylori Eradication
    Hayashi, Tomoyuki
    Asahina, Yoshiro
    Okafuji, Hirofumi
    Nakanishi, Hiroyoshi
    Takatori, Hajime
    Kitamura, Kazuya
    Sawada, Takeshi
    Kaneko, Shuichi
    [J]. GASTROINTESTINAL ENDOSCOPY, 2017, 85 (05) : AB462 - AB463
  • [9] Risk of gastric cancer development after eradication of Helicobacter pylori
    Cheung, Ka-Shing
    Leung, Wai K.
    [J]. WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2018, 10 (05) : 115 - 123
  • [10] Detection of Early Gastric Cancer after Helicobacter pylori Eradication
    Shichijo, Satoki
    Uedo, Noriya
    Michida, Tomoki
    [J]. DIGESTION, 2022, 103 (01) : 54 - 61