Characteristics and Early Diagnosis of Gastric Cancer Discovered after Helicobacter pylori Eradication

被引:18
|
作者
Ito, Masanori [1 ]
Tanaka, Shinji [2 ]
Chayama, Kazuaki [3 ]
机构
[1] Hiroshima Univ Hosp, Dept Gen Internal Med, Hiroshima, Japan
[2] Hiroshima Univ Hosp, Dept Endoscopy, Hiroshima, Japan
[3] Hiroshima Univ Hosp, Dept Gastroenterol & Metab, Hiroshima, Japan
关键词
Stomach neoplasms; Eradication therapy; Helicobacter pylori; Reddish depression; Epithelium with low-grade atypia; ENDOSCOPIC RESECTION; INTESTINAL METAPLASIA; TUMOR-GROWTH; FEATURES; INFECTION; CARCINOMA; THERAPY; ATROPHY; MUCOSA; RISK;
D O I
10.5009/gnl19418
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The prevalence of gastric cancer after eradication (GCAE) is increasing dramatically in Japan. GCAE has characteristic features, and we must understand these features in endoscopic examinations. Differentiated cancer types were frequently found after eradication and included characteristic endoscopic features such as reddish depression (RD). However, benign RD can be difficult to distinguish from gastric cancer because of histological alterations in the surface structures (nonneoplastic epithelium or epithelium with low-grade atypia [ELA]) as well as multiple appearances of RD. Recently, we clarified similar alterations in genetic mutations between ELA and gastric cancer, suggesting that ELA is derived from gastric cancer. Clinically, submucosal invasive cancer was frequently found in patients after eradication therapy even if they received annual endoscopic surveillance. We can improve the diagnostic ability using image-enhanced endoscopy with magnified observation.
引用
收藏
页码:338 / 345
页数:8
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