Mild deprotection of tert-butyl carbamates of NH-heteroarenes under basic conditions

被引：26
|
作者：
Chakrabarty, Manas
Kundu, Taraknath
Harigaya, Yoshihiro
机构：
[1] Bose Inst, Dept Chem, Kolkata 700009, India
[2] Kitasato Univ, Sch Pharmaceut Sci, Tokyo 108, Japan
来源：
SYNTHETIC COMMUNICATIONS | 2006年 / 36卷 / 14期
关键词：
aqueous K2CO3/MeOH; N-Boc-heteroarenes; deprotection; reflux;
D O I：
10.1080/00397910600634480
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Aqueous methanolic potassium carbonate under reflux has been demonstrated to be a highly effective deprotective agent for the tert -butyl carbamates of indoles, indazoles, carbazole, thiazoloindole, and pyrrole. The method is a mild one and is particularly expeditious for NH-heteroarenes bearing electron-withdrawing groups.
引用
收藏
页码：2069 / 2077
页数：9
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