Florisil as an efficient reagent for deprotection of tert-butyl carbamates, carbonates and esters

被引：1

作者：

Liu, Cheng-Hang ^{[1
]}

Xu, Mengyang ^{[1
]}

Luo, Qiyun ^{[1
]}

Wang, Ziyan ^{[1
,2
]}

Tan, Wenyue ^{[1
,2
]}

Zhao, Xingzeng ^{[1
]}

Jia, Xiaodong ^{[1
]}

机构：

[1] Jiangsu Prov & Chinese Acad Sci, Inst Bot, Jiangsu Key Lab Res & Utilizat Plant Resources, Nanjing Bot Garden,Mem Sun Yat Sen, Nanjing 210014, Jiangsu, Peoples R China

[2] Nanjing Univ Chinese Med, Nanjing 210023, Jiangsu, Peoples R China

来源：

TETRAHEDRON | 2024年 / 155卷

关键词：

Florisil; Boc group; Deprotection; tert-Butyl carbamates; N-BOC DEPROTECTION; SILICA-GEL; AMINES; ACID; MILD; BUTOXYCARBONYLATION; CLEAVAGE; METHODOLOGIES; ALCOHOLS; KINETICS;

D O I：

10.1016/j.tet.2024.133904

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Florisil (magnesium polysilicate) is an efficient and eco-friendly reagent for the deprotection of tert-butyl carbamates, carbonates, and ethers. Moderate to excellent yields could be achieved in the presence of other acidsensitive groups. The separation of products is easy, and Florisil can be recycled several times without observing a decrease in yields.

引用

页数：5

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