In Vitro Activity of New Tetracycline Analogs Omadacycline and Eravacycline against Drug-Resistant Clinical Isolates of Mycobacterium abscessus

被引：6
|
作者：
Kaushik, Amit [1 ]
Ammerman, Nicole C. [1 ]
Martins, Olumide [1 ]
Parrish, Nicole M. [2 ]
Nuermberger, Eric L. [1 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Ctr TB Res, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2019年 / 63卷 / 06期
基金：
美国国家卫生研究院;
关键词：
Mycobacterium abscessus; omadacycline; drug susceptibility assay; eravacycline; tetracyclines; tigecycline; RAPIDLY GROWING MYCOBACTERIA; NONTUBERCULOUS MYCOBACTERIA; LUNG-DISEASE; TIGECYCLINE; EPIDEMIOLOGY; INFECTIONS; GENE;
D O I：
10.1128/AAC.00470-19
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Tigecycline is used in multidrug regimens for salvage therapy of Mycobacterium abscessus infections but is often poorly tolerated and has no oral formulation. Here, we report similar in vitro activity of two newly approved tetracycline analogs, omadacycline and eravacycline, against 28 drug-resistant clinical isolates of M. abscessus complex. Since omadacycline and eravacycline appear to be better tolerated than tigecycline and since omadacycline is also formulated for oral dosing, these tetracycline analogs may represent new treatment options for M. abscessus infections.
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页数：5
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