In Vitro Activity of New Tetracycline Analogs Omadacycline and Eravacycline against Drug-Resistant Clinical Isolates of Mycobacterium abscessus

被引：6
|
作者：
Kaushik, Amit [1 ]
Ammerman, Nicole C. [1 ]
Martins, Olumide [1 ]
Parrish, Nicole M. [2 ]
Nuermberger, Eric L. [1 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Ctr TB Res, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2019年 / 63卷 / 06期
基金：
美国国家卫生研究院;
关键词：
Mycobacterium abscessus; omadacycline; drug susceptibility assay; eravacycline; tetracyclines; tigecycline; RAPIDLY GROWING MYCOBACTERIA; NONTUBERCULOUS MYCOBACTERIA; LUNG-DISEASE; TIGECYCLINE; EPIDEMIOLOGY; INFECTIONS; GENE;
D O I：
10.1128/AAC.00470-19
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Tigecycline is used in multidrug regimens for salvage therapy of Mycobacterium abscessus infections but is often poorly tolerated and has no oral formulation. Here, we report similar in vitro activity of two newly approved tetracycline analogs, omadacycline and eravacycline, against 28 drug-resistant clinical isolates of M. abscessus complex. Since omadacycline and eravacycline appear to be better tolerated than tigecycline and since omadacycline is also formulated for oral dosing, these tetracycline analogs may represent new treatment options for M. abscessus infections.
引用
收藏
页数：5
相关论文
共 50 条
  • [1] In Vitro Activity of New Tetracycline Analogues Eravacycline and Omadacycline Against Drug-Resistant Mycobacterium Abscessus Clinical Isolates
    Kaushik, A.
    Nuermberger, E. L.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2019, 199
  • [2] In vitro activity of new tetracycline analogues omadacycline and eravacycline against clinical isolates of Helicobacter pylori collected in China
    Yang, Yanmei
    Bian, Lijun
    Hang, Xudong
    Yan, Caiwang
    Huang, Yan
    Ye, Feng
    Zhang, Guoxin
    Jin, Guangfu
    Bi, Hongkai
    DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2020, 98 (03)
  • [3] Omadacycline, Eravacycline, and Tigecycline Express Anti-Mycobacterium abscessus Activity In Vitro
    Li, Anqi
    He, Siyuan
    Li, Jingren
    Zhang, Zhemin
    Li, Bing
    Chu, Haiqing
    MICROBIOLOGY SPECTRUM, 2023, 11 (03):
  • [4] In vitro activity of tetracycline analogs against multidrug-resistant and extensive drug resistance clinical isolates of Mycobacterium tuberculosis
    Zhang, Chi
    Ouyang, Qi
    Zhou, Xianyuan
    Huang, Yingfeng
    Zeng, Yu
    Deng, Li
    Lin, Dachuan
    Zheng, Weidong
    TUBERCULOSIS, 2023, 140
  • [5] Evaluating the Efficacy of Eravacycline and Omadacycline against Extensively Drug-Resistant Acinetobacter baumannii Patient Isolates
    Deolankar, Manas S.
    Carr, Rachel A.
    Fliorent, Rebecca
    Roh, Sean
    Fraimow, Henry
    Carabetta, Valerie J.
    ANTIBIOTICS-BASEL, 2022, 11 (10):
  • [6] Antimicrobial Efficacy of Decamethoxin (DMT) Against Drug-Resistant Mycobacterium Abscessus Clinical Isolates
    Faasuamalie, P.
    Gupta, S.
    Olivier, K. N.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2022, 205
  • [7] In vitro antimicrobial activity and resistance mechanisms of the new generation tetracycline agents, eravacycline, omadacycline, and tigecycline against clinical Staphylococcus aureus isolates
    Zeng, Weiliang
    Zhang, Xiaotuan
    Liu, Yan
    Zhang, Yi
    Xu, Mengxin
    Wang, Sipei
    Sun, Yao
    Zhou, Tieli
    Chen, Lijiang
    FRONTIERS IN MICROBIOLOGY, 2022, 13
  • [8] Omadacycline enhances the in vitro activity of clofazimine against Mycobacterium abscessus
    Mudde, S. E.
    Meliefste, H. M.
    Ammerman, N. C.
    DE Steenwinkel, J. E. M.
    Bax, H. I.
    INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 2024, 28 (11) : 554 - 556
  • [9] In vitro activity of rifabutin against Mycobacterium abscessus, clinical isolates
    Chen, Jianhui
    Zhang, Haonan
    Guo, Qi
    He, Siyuan
    Xu, Liyun
    Zhang, Zhemin
    Ma, Jian
    Chu, Haiqing
    CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2022, 49 (07) : 767 - 775
  • [10] Efficacy of Disulfiram Against Drug Resistant Mycobacterium Abscessus Clinical Isolates
    Winters, C.
    Gupta, S.
    Olivier, K. N.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2021, 203 (09)
12345