Saponins as vaccine adjuvants

被引：0
|
作者：
Kensil, CR
机构：
来源：
CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS | 1996年 / 13卷 / 1-2期
关键词：
Quillaja saponaria; adjuvant; vaccine; Quil A; QS-21;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Naturally occurring triterpene glycosides (saponins) from Quillaja saponaria have considerable adjuvant activity. Adjuvant functions include stimulation of high levels of antibody to T-dependent and T-independent antigens, induction of mouse IgG1, IgG2b, and IgG2a isotypes, and induction of cytotoxic T lymphocyte responses. This article reviews responses due to specific saponins or saponin preparations, effect of formulation, structure/function studies, and use in different preclinical and clinical vaccine applications.
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页码：1 / 55
页数：55
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