Fungi sensing environmental stress

被引：42

作者：

Alonso-Monge, R. ^{[1
]}

Roman, E. ^{[1
]}

Arana, D. M. ^{[1
]}

Pla, J. ^{[1
]}

Nombela, C. ^{[1
]}

机构：

[1] Univ Complutense Madrid, Fac Farm, Dept Microbiol 2, E-28040 Madrid, Spain

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2009年 / 15卷

关键词：

Candida albicans; fungi; mitogen-activated protein kinase; signal transduction; ACTIVATED PROTEIN-KINASE; PATHOGEN CANDIDA-ALBICANS; RESPONSE REGULATOR GENE; CELL-WALL BIOSYNTHESIS; OXIDATIVE-STRESS; MORPHOGENESIS; VIRULENCE; MKC1; PHAGOCYTES; MUTANTS;

D O I：

10.1111/j.1469-0691.2008.02690.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Cells need to adapt to the external environment in order to survive. Signal transduction pathways are crucial mechanisms that allow cells to sense and respond to extracellular stimuli. Among the signal transduction pathways, we point out the cascades mediated by mitogen-activated protein kinases (MAPKs). The MAPKs are conserved from yeast to human and play relevant roles in the physiology of the cell. In pathogenic fungi these MAPK pathways control virulence factors. This review describes the MAPK cascades described in Candida albicans, the most frequently isolated fungus, from fungal systemic infections among individuals in developed countries.

引用

页码：17 / 19

页数：3

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