Characteristics of single ionic channels induced by sulfonic acid derivatives of dibenzo-18-crown-6 in bilayers

被引：2
|
作者：
Yarishkin, OV
Tashmukhamedova, AK
Mirkhodjaev, UZ [1 ]
Tashmukhamedov, BA
机构：
[1] Natl Univ Uzbekistan, Tashkent 700174, Vuzgorodok, Uzbekistan
[2] Inst Physiol & Biophys, Tashkent 700095, Uzbekistan
来源：
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | 2004年 / 49卷 / 1-2期
关键词：
bilayer lipid membrane; crown ether; ionic channel;
D O I：
10.1023/B:JIPH.0000031127.96079.62
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Sulfonic acid derivatives of dibenzo-18-crown-6 (DB18C6) have been shown to induce formation of ion channels permeable to monovalent cations in bilayer lipid membranes (BLM). Some electric characteristics of channels have been studied by means of the voltage clamp method. Channels displayed little interionic discrimination. The voltage dependence as well as the multiple state behaviors of the channels functioning was observed. The channels formation has been shown to be dependent on pH of bath solutions and on the presence of bivalent cations in them. The channels supposed to be formed from aggregates of complexes associates assembled in aqueous salt solutions.
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页码：139 / 144
页数：6
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