The effect of exercise training on adiponectin receptor expression in KKAy obese/diabetic mice

被引:41
|
作者
Huang, Hu
Iida, Kaoruko Tada
Sone, Hirohito
Yokoo, Tomotaka
Yamada, Nobuhiro
Ajisaka, Ryuichi
机构
[1] Univ Tsukuba, Grad Sch Comprehens Human Sci, Doctoral Program Sports Med, Tsukuba, Ibaraki 3058575, Japan
[2] Univ Tsukuba, Grad Sch Comprehens Human Sci, Doctoral Program Adv Biomed Applicat, Tsukuba, Ibaraki 3058575, Japan
关键词
D O I
10.1677/joe.1.06630
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Adiponectin is an adipocyte-derived factor that plays a pivotal role in lipid and glucose metabolism. Recently, two types of adiponectin receptors (AdipoR1 and AdipoR2) were identified. We investigated whether exercise training (ET) or dietary restriction (DR) affects the expression of adiponectin receptors in skeletal muscle and liver, thereby improving glucose and lipid metabolism in KKAy mice. KKAy mice were subjected to 8 weeks of exercise training or food restriction. Following the experimental protocol, an intravenous glucose tolerance test and an intraperitoneal insulin tolerance test were performed in addition to the measurement of blood lipid and adiponectin concentrations. The mRNA levels of adiponectin, adiponectin receptors and genes that are putatively regulated by the adiponectin receptors were also analyzed. Both the 8-week exercise training and food restriction protocol improved insulin resistance in KKAy mice but did not alter plasma adiponectin concentration nor its mRNA expression. In comparison with C57BL/6 mice, AdipoR1 expression level was significantly decreased in skeletal muscle and AdipoR2 expression level was significantly increased in the liver in KKAy mice. After the 8-week experimental protocol, the expression level of AdipoR1 mRNA was approximately 1-8-fold greater in the skeletal muscle and 1(.)3-fold greater in the liver, and the level of AdipoR2 mRNA was 30% less in the liver of the ET group as compared with the control group. Additionally, in the ET group, mRNA expression of acyl coenzyme A-oxidase and carnitine palmitoyl transferase 1 (CPT1) was greater in the liver but not in skeletal muscle. In contrast, no significant changes were observed in the expression of genes encoding the adiponectin receptors in addition to other genes except for CPT1 in the DR group. These findings suggest that chronic exercise training affects the expression level of adiponectin receptors thereby improving insulin resistance in KKAy mice.
引用
收藏
页码:643 / 653
页数:11
相关论文
共 50 条
  • [31] The kidney expression of matrix metalloproteinase-9 in the diabetic nephropathy of Kkay mice
    Guo Qing-Hua
    Lu Ju-Ming
    Pan Chang-Yu
    Lu Zhao-Hui
    Zou Xiao-Man
    Mu Yi-Ming
    JOURNAL OF DIABETES AND ITS COMPLICATIONS, 2008, 22 (06) : 408 - 412
  • [32] The regulation of adiponectin receptors expression by acute exercise in mice
    Huang, H.
    Licia, K. T.
    Sone, H.
    Ajisaka, R.
    EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 2007, 115 (07) : 417 - 422
  • [33] Effect of mineralocorticoid receptor blockade on expression of adiponectin in hearts of db/db mice
    Lian, Christine
    Ricchiuti, Vincent
    Yao, Tham
    Li, Jianmin
    Williams, Gordon
    Adler, Gail
    HYPERTENSION, 2007, 50 (04) : E127 - E128
  • [34] The combined effects of physical exercise training and detraining on adiponectin in overweight and obese children
    Jeon, Jae-Young
    Han, Jin
    Kim, Hyun-Jun
    Park, Moon Soo
    Seo, Dae Yun
    Kwak, Yi-Sub
    INTEGRATIVE MEDICINE RESEARCH, 2013, 2 (04) : 145 - 150
  • [35] Obese and diabetic KKAy mice show increased mortality but improved cardiac function following myocardial infarction
    Heaberlin, James R.
    Ma, Yonggang
    Zhang, Jianhua
    Ahuja, Seema S.
    Lindsey, Merry L.
    Halade, Ganesh V.
    CARDIOVASCULAR PATHOLOGY, 2013, 22 (06) : 481 - 487
  • [36] Overexpression of Adiponectin Receptor Improves the Phenotypes of TALLYHO Diabetic Mice
    Luo, Nanlan
    Chung, Hong
    Garvey, W. Timothy
    Fu, Yuchang
    DIABETES, 2012, 61 : A415 - A415
  • [37] Chemokine and chemokine receptor gene expression in the mesenteric adipose tissue of KKAy mice
    Lee, Han-Sam
    Park, Jin-Hee
    Kang, Ji-Hye
    Kawada, Teruo
    Yu, Rina
    Han, In-Seob
    CYTOKINE, 2009, 46 (02) : 160 - 165
  • [38] Exercise does not activate the β3 adrenergic receptor–eNOS pathway, but reduces inducible NOS expression to protect the heart of obese diabetic mice
    Adrien Kleindienst
    Sylvain Battault
    Elise Belaidi
    Stephane Tanguy
    Marie Rosselin
    Doria Boulghobra
    Gregory Meyer
    Sandrine Gayrard
    Guillaume Walther
    Bernard Geny
    Gregory Durand
    Olivier Cazorla
    Cyril Reboul
    Basic Research in Cardiology, 2016, 111
  • [39] EXERCISE TRAINING IN OBESE DIABETIC-PATIENTS - SPECIAL CONSIDERATIONS
    ZIERATH, JR
    WALLBERGHENRIKSSON, H
    SPORTS MEDICINE, 1992, 14 (03) : 171 - 189
  • [40] Niacin Increases Adiponectin in Obese Mice in a Receptor-Dependent Manner
    Wanders, Desiree
    Graff, Emily C.
    Plaisance, Eric P.
    Judd, Robert L.
    DIABETES, 2012, 61 : A436 - A436