Transplantation of Human Embryonic Stem Cell-Derived Endothelial Cells for Vascular Diseases

被引：50
|
作者：
Li, Zongjin [1 ,2 ]
Han, Zhongchao [3 ,4 ]
Wui, Joseph C. [1 ,2 ,5 ]
机构：
[1] Stanford Univ, Sch Med, Dept Radiol, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, MIPS, Stanford, CA 94305 USA
[3] Peking Union Med Coll, Tianjin, Peoples R China
[4] Chinese Acad Med Sci, Inst Hematol, State Key Lab Expt Hematol, Tianjin, Peoples R China
[5] Stanford Univ, Sch Med, Dept Med, Div Cardiol, Stanford, CA 94305 USA
来源：
JOURNAL OF CELLULAR BIOCHEMISTRY | 2009年 / 106卷 / 02期
关键词：
HUMAN EMBRYONIC STEM CELLS; ENDOTHELIAL CELLS; DIFFERENTIATION; TRANSPLANTATION; MOLECULAR IMAGING; BLOOD MONONUCLEAR-CELLS; IN-VITRO; AUTOLOGOUS TRANSPLANTATION; HINDLIMB ISCHEMIA; HUMAN BLASTOCYSTS; DIFFERENTIATION; LINES; NEOVASCULARIZATION; CARDIOMYOCYTES; ANGIOGENESIS;
D O I：
10.1002/jcb.22003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Using endothelial cells for therapeutic angiogenesis/vasculogenesis of ischemia diseases has led to exploring human embryonic stem cells (hESCs) as a potentially unlimited source for endothelial progenitor cells. With their capacity for self-renewal and pluripotency, hESCs and their derived endothelial cells (hESC-ECs) may be more advantageous than other endothelial cells obtained from diseased populations. However, hESC-ECs' poor differentiation efficiency and poorly characterized in vivo function after transplantation present significant challenges for their future clinical application. This review will focus on the differentiation pathways of hESCs and their therapeutic potential for vascular diseases, as well as the monitoring of transplanted cells' fate via molecular imaging. Finally, cell enhancement strategies to improve the engraftment efficiency of hESC-ECs will be discussed. J. Cell. Biochem. 106: 194-199, 2009. (C) 2008 Wiley-Liss, Inc.
引用
收藏
页码：194 / 199
页数：6
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