Macrophages Generate Pericytes in the Developing Brain

被引：22

作者：

Prazeres, Pedro H. D. M. ^{[1
]}

Almeida, Viviani M. ^{[1
]}

Lousado, Luiza ^{[1
]}

Andreotti, Julia P. ^{[1
]}

Paiva, Ana E. ^{[1
]}

Santos, Gabryella S. P. ^{[1
]}

Azevedo, Patrick O. ^{[1
]}

Souto, Luanny ^{[1
]}

Almeida, Gregorio G. ^{[1
]}

Filev, Renato ^{[2
]}

Mintz, Akiva ^{[3
]}

Goncalves, Ricardo ^{[1
]}

Birbrair, Alexander ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Dept Pathol, Belo Horizonte, MG, Brazil

[2] Univ Fed Sao Paulo, Neurobiol Lab, Sao Paulo, SP, Brazil

[3] Columbia Univ, Dept Radiol, Med Ctr, New York, NY USA

来源：

CELLULAR AND MOLECULAR NEUROBIOLOGY | 2018年 / 38卷 / 04期

关键词：

Pericytes; Brain; Development; Origin; VASCULAR SMOOTH-MUSCLE; NEURAL CREST; TRANSGENIC MICE; CELLS; DIFFERENTIATION; REGENERATION; ORIGIN; NICHE; HETEROGENEITY; MESOTHELIUM;

D O I：

10.1007/s10571-017-0549-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pericytes are defined by their anatomical location encircling blood vessels' walls with their long projections. The exact embryonic sources of cerebral pericytes remain poorly understood, especially because of their recently revealed diversity. Yamamoto et al. (Sci Rep 7(1):3855, 2017) using state-of-the-art techniques, including several transgenic mice models, reveal that a subpopulation of brain pericytes are derived from phagocytic macrophages during vascular development. This work highlights a new possible ancestor of brain pericytes. The emerging knowledge from this research may provide new approaches for the treatment of several neurodevelopmental disorders in the future.

引用

页码：777 / 782

页数：6

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