Modeling Cancer with Pluripotent Stem Cells

被引：28

作者：

Gingold, Julian ^{[1
]}

Zhou, Ruoji ^{[2
,3
]}

Lemischka, Ihor R. ^{[4
,5
,6
]}

Lee, Dung-Fang ^{[2
,3
,7
]}

机构：

[1] Cleveland Clin Fdn, Womens Hlth Inst, Cleveland, OH 44195 USA

[2] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Integrat Biol & Pharmacol, Houston, TX 77030 USA

[3] Univ Texas Houston, Grad Sch Biomed Sci Houston, Houston, TX 77030 USA

[4] Icahn Sch Med Mt Sinai, Dept Dev & Regenerat Biol, New York, NY 10029 USA

[5] Icahn Sch Med Mt Sinai, Dept Pharmacol & Syst Therapeut, New York, NY 10029 USA

[6] Icahn Sch Med Mt, Black Family Stem Cell Inst, New York, NY 10029 USA

[7] Univ Texas Hlth Sci Ctr Houston, Ctr Stem Cell & Regenerat Med, Brown Fdn, Inst Mol Med Prevent Human Dis, Houston, TX 77030 USA

来源：

TRENDS IN CANCER | 2016年 / 2卷 / 09期

关键词：

TARGETED GENE CORRECTION; FUNCTIONAL HUMAN LIVER; KIDNEY ORGANOIDS; HUMAN ES; DIRECTED DIFFERENTIATION; PROGENITOR CELLS; SELF-RENEWAL; IPS CELLS; GENERATION; DISEASE;

D O I：

10.1016/j.trecan.2016.07.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The elucidation of cancer pathogenesis has been hindered by limited access to patient samples, tumor heterogeneity, and the lack of reliable model organisms. Characterized by their ability to self-renew indefinitely and differentiate into all adult cell lineages of an organism, pluripotent stem cells (PSCs), including ESCs and induced pluripotent stem cells (iPSCs), provide a powerful and unlimited source to generate differentiated cells that can be used to study disease biology, facilitate drug discovery and development, and provide key insights for developing personalized therapies. This article reviews the recent developments and technologies converting PSCs into clinically relevant model systems for cancer research.

引用

页码：485 / 494

页数：10

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