Gender differences in the behavioral effects of methamphetamine

被引：73
|
作者：
Schindler, CW [1 ]
Bross, JG [1 ]
Thorndike, EB [1 ]
机构：
[1] NIDA, Preclin Pharmacol Sect, Intramural Res Program, NIH, Baltimore, MD 21224 USA
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2002年 / 442卷 / 03期
关键词：
methamphetamine; locomotor activity; place preference; sex; (rat);
D O I：
10.1016/S0014-2999(02)01550-9
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of methamphetamine were tested in male and female rats on two different behavioral tasks. Following habituation to a locomotor activity chamber, female rats were more sensitive to the locomotor activating effect of i.p. methamphetamine (0.1-3.0 mg/kg) than were male rats. A similar effect has been observed for other psychomotor stimulants, including cocaine and amphetamine. However, males and females did not differ on methamphetamine-induced place preference following eight conditioning trials with a wide range of doses (0.1-5.6 mg/kg). These results suggest that males and females differ in their response to methamphetamine for only some behavioral tasks. Published by Elsevier Science B.V.
引用
收藏
页码：231 / 235
页数：5
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