An adult patient with 49, XXXXY syndrome: further clinical and biological delineation

被引:1
|
作者
Collet, Agnes [1 ]
Chatelin, Jerome [2 ]
Agopiantz, Mikael [2 ]
Valduga, Mylene [1 ]
Bonnet, Celine [1 ]
Allou, Lila [1 ]
Lambert, Laetitia [1 ]
Gospodaru, Razvan Nicolaie [3 ]
Weryha, Georges [2 ]
Jonveaux, Philippe [1 ]
机构
[1] Univ Lorraine, Ctr Hosp Nancy, Genet Lab, INSERM,U954, Vandoeuvre Les Nancy, France
[2] Univ Lorraine, Ctr Hosp Nancy, Serv Endocrinol & Gynecol Med, Vandoeuvre Les Nancy, France
[3] Univ Lorraine, Ctr Hosp Univ Nancy, Serv Neurol, Nancy, France
关键词
aneuploidy; 49; XXXY syndrome; KLINEFELTER-SYNDROME; 49; XXXXY SYNDROME; 48; XXYY; PHENOTYPE; ANEUPLOIDIES;
D O I
10.1684/abc.2014.0954
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
49, XXXXY syndrome is a rare sex chromosome aneuploidy occurring in 1:80 000-1:100 000 male births. Data on this aneuploidy in adulthood are limited, with most of the literature data based on paediatric patients. We report a new male patient whose 49, XXXXY diagnosis was formally made at the age of 54 years. So far, no medical follow-up was performed specifically for his condition. This man presented with facial features (epicanthus, hypertelorism, up-slanting palpebral fissures), microorchidism and features of chronic hypoandrogenism with muscular weakness, sparse body hair, dry skin with abnormal healing of skin wounds. Endocrine evaluation confirmed a hypergonadotropic hypogonadism. He had moderate intellectual deficiency with more affected verbal skills. A recent deep vein thrombosis was diagnosed in his left leg. Unusually, in addition to moderate deafness, he developed progressively a severe vision impairment leading to blindness. There have been very few reports of adult individuals with 49, XXXXY syndrome and this kind of report may contribute to improved management of prospective medical healthcare associated with this condition in older individuals.
引用
收藏
页码:371 / 377
页数:7
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