Objective: To summarize the perioperative nursing intervention of thyroidectomy and experience in the integration of medical treatment and nursing. Methods: The clinical data of 1,568 patients with thyroid tumor who were admitted in our hospital from June 2008 to May 2013 were analyzed retrospectively, and the observations and treatment of the perioperative and postoperative complications were summarized. Results: All these 1,568 patients undergoing surgical treatment had active cooperation during the preoperative nursing and smoothly went through the perioperative period. Postoperative complications occurred in 140 patients, in which, bleeding occurred in 16 patients, dyspnea in 12 patients, shivering and fever in 2 patients, hoarseness in 33 patients, drinking cough in 32 patients, limb twitch in 21 patients and lip numb in 24 patients. All patients were then given aggressive treatment and discharged from hospital. Extubation was done in 5 intubated patients 3-7 days after the surgery, and extubation was done in 2 patients who received tracheostomy 20 days after surgery. 1 patient with dyspnea after surgery received tracheostomy, and extubation was performed after 6 months. No death occurred in these patients. All patients experienced good recovery and were free of permanent complications during a following-up period from 6 months to 5 years after surgery. Conclusion: Postoperative recovery can be promoted if the patients are given complete preoperative evaluation and preparation, postoperative careful nursing, close observation of postoperative complications, close cooperation of medical treatment and nursing, thus improving the cute rate and quality of life.