Vaginal Myeloid Dendritic Cells Transmit Founder HIV-1

被引：37
|
作者：
Shen, Ruizhong [1 ]
Kappes, John C. [2 ,5 ]
Smythies, Lesley E. [1 ]
Richter, Holly E. [3 ]
Novak, Lea [4 ]
Smith, Phillip D. [1 ,5 ]
机构：
[1] Univ Alabama Birmingham, Dept Med Gastroenterol, Birmingham, AL 35203 USA
[2] Univ Alabama Birmingham, Dept Hematol Oncol, Birmingham, AL USA
[3] Univ Alabama Birmingham, Dept Obstet & Gynecol, Birmingham, AL 35294 USA
[4] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA
[5] VA Med Ctr Res Serv, Birmingham, AL USA
来源：
JOURNAL OF VIROLOGY | 2014年 / 88卷 / 13期
基金：
美国国家卫生研究院;
关键词：
HUMAN-IMMUNODEFICIENCY-VIRUS; HUMAN RECTAL MUCOSA; DC-SIGN; INTRAVAGINAL INOCULATION; VIRAL DISSEMINATION; LANGERHANS CELLS; RHESUS MACAQUES; INFECTION; BINDING; TYPE-1;
D O I：
10.1128/JVI.00766-14
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Wereport that primary human vaginal dendritic cells (DCs) display a myeloid phenotype and express CD4, CCR5, and CXCR4. Vaginal CD13(+) CD11c(+) DCs rapidly and efficiently bound transmitted/founder (T/F) CCR5-tropic (R5) viruses, transported them through explanted vaginal mucosa, and transmitted them in trans to vaginal and blood lymphocytes. Vaginal myeloid DCs may play a key role in capturing and disseminating T/F R5 HIV-1 in vivo and are candidate "gatekeeper" cells in HIV-1 transmission.
引用
收藏
页码：7683 / 7688
页数：6
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