Vermelhotin, an Anti-inflammatory Agent, Suppresses Nitric Oxide Production in RAW 264.7 Cells via p38 Inhibition

被引：23

作者：

Pansanit, Acharavadee ^{[1
,2
]}

Park, Eun-Jung ^{[3
]}

Kondratyuk, Tamara P. ^{[3
]}

Pezzuto, John M. ^{[3
]}

Lirdprapamongkol, Kriengsak ^{[4
]}

Kittakoop, Prasat ^{[1
,2
,4
]}

机构：

[1] Chulabhorn Grad Inst, Chem Biol Program, Bangkok 10210, Thailand

[2] Minist Educ, CHE, Ctr Excellence Environm Hlth & Toxicol EHT, Bangkok, Thailand

[3] Univ Hawaii, Coll Pharm, Hilo, HI 96720 USA

[4] Chulabhorn Res Inst, Bangkok 10210, Thailand

来源：

JOURNAL OF NATURAL PRODUCTS | 2013年 / 76卷 / 09期

关键词：

FUNGUS ASPERGILLUS-UNGUIS; MARINE-DERIVED FUNGI; CALMODULIN INHIBITOR; KAPPA-B; BIOSYNTHESIS; INFLAMMATION; MACROPHAGES;

D O I：

10.1021/np400565e

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Vermelhotin exhibited potential anti-inflammatory activity through inhibition of nitric oxide production (IC50 = 5.35 +/- 0.59 mu M) in LPS-stimulated RAW 264.7 macrophage cells. Vermelhotin suppressed expression of inducible nitric oxide synthase (iNOS) at mRNA and protein levels, in a dose-dependent manner. Mechanistic studies revealed that vermelhotin abrogated upstream signaling of iNOS expression by selectively inhibiting p38 phosphorylation, while ERK and JNK activations were not affected.

引用

页码：1824 / 1827

页数：4

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