Vermelhotin, an Anti-inflammatory Agent, Suppresses Nitric Oxide Production in RAW 264.7 Cells via p38 Inhibition

被引：23
|
作者：
Pansanit, Acharavadee [1 ,2 ]
Park, Eun-Jung [3 ]
Kondratyuk, Tamara P. [3 ]
Pezzuto, John M. [3 ]
Lirdprapamongkol, Kriengsak [4 ]
Kittakoop, Prasat [1 ,2 ,4 ]
机构：
[1] Chulabhorn Grad Inst, Chem Biol Program, Bangkok 10210, Thailand
[2] Minist Educ, CHE, Ctr Excellence Environm Hlth & Toxicol EHT, Bangkok, Thailand
[3] Univ Hawaii, Coll Pharm, Hilo, HI 96720 USA
[4] Chulabhorn Res Inst, Bangkok 10210, Thailand
来源：
JOURNAL OF NATURAL PRODUCTS | 2013年 / 76卷 / 09期
关键词：
FUNGUS ASPERGILLUS-UNGUIS; MARINE-DERIVED FUNGI; CALMODULIN INHIBITOR; KAPPA-B; BIOSYNTHESIS; INFLAMMATION; MACROPHAGES;
D O I：
10.1021/np400565e
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Vermelhotin exhibited potential anti-inflammatory activity through inhibition of nitric oxide production (IC50 = 5.35 +/- 0.59 mu M) in LPS-stimulated RAW 264.7 macrophage cells. Vermelhotin suppressed expression of inducible nitric oxide synthase (iNOS) at mRNA and protein levels, in a dose-dependent manner. Mechanistic studies revealed that vermelhotin abrogated upstream signaling of iNOS expression by selectively inhibiting p38 phosphorylation, while ERK and JNK activations were not affected.
引用
收藏
页码：1824 / 1827
页数：4
相关论文
共 50 条
  • [1] Carabrol suppresses LPS-induced nitric oxide synthase expression by inactivation of p38 and JNK via inhibition of I-κBα degradation in RAW 264.7 cells
    Lee, Hwa Jin
    Lim, Hyo Jin
    Lee, Da Yeon
    Jung, Hyeyoun
    Kim, Mi-Ran
    Moon, Dong-Cheul
    Kim, Keun Il
    Lee, Myeong-Sok
    Ryu, Jae-Ha
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 391 (03) : 1400 - 1404
  • [2] ANTI-INFLAMMATORY EFFECTS OF LANSOPRAZOLE BY INHIBITING NITRIC OXIDE PRODUCTION VIA REACTIVE OXYGEN SPECIES IN MURINE MACROPHAGE RAW 264.7 CELLS
    Ichimaru, S.
    Nakagawa, S.
    Arai, Y.
    Tsuchida, S.
    Inoue, H.
    Matsuki, T.
    Taniguchi, D.
    Oda, R.
    Fujiwara, H.
    Kubo, T.
    [J]. OSTEOARTHRITIS AND CARTILAGE, 2014, 22 : S291 - S292
  • [3] Anti-inflammatory activity of the synthetic chalcone derivatives: Inhibition of inducible nitric oxide synthase-catalyzed nitric oxide production from lipopolysaccharide-treated RAW 264.7 cells
    Kim, Young Hoon
    Kim, Jeongsoo
    Park, Haeil
    Kim, Hyun Pyo
    [J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2007, 30 (08) : 1450 - 1455
  • [4] Melatonin suppresses nitric oxide production in glial cultures by pro-inflammatory cytokines through p38 MAPK inhibition
    Vilar, A.
    de Lemos, L.
    Patraca, I.
    Martinez, N.
    Folch, J.
    Junyent, F.
    Verdaguer, E.
    Pallas, M.
    Auladell, C.
    Camins, A.
    [J]. FREE RADICAL RESEARCH, 2014, 48 (02) : 119 - 128
  • [5] Roxatidine Suppresses Inflammatory Responses Via Inhibition of NF-κB and p38 MAPK Activation in LPS-Induced RAW 264.7 Macrophages
    Cho, Eu-Jin
    An, Hyo-Jin
    Shin, Ji-Sun
    Choi, Hye-Eun
    Ko, Jane
    Cho, Young-Wuk
    Kim, Hyung-Min
    Choi, Jung-Hye
    Lee, Kyung-Tae
    [J]. JOURNAL OF CELLULAR BIOCHEMISTRY, 2011, 112 (12) : 3648 - 3659
  • [6] Anti-inflammatory activity of aucubin by inhibition of tumor necrosis factor-α production in RAW 264.7 cells
    Park, KS
    Chang, IM
    [J]. PLANTA MEDICA, 2004, 70 (08) : 778 - 779
  • [7] Wistin Exerts an Anti-Inflammatory Effect via Nuclear Factor-κB and p38 Signaling Pathways in Lipopolysaccharide-Stimulated RAW264.7 Cells
    An, Jangeun
    Ryu, Gyoungah
    Shin, Seong-Ah
    Kim, Huiji
    Ahn, Mi-Jeong
    Lee, Jun Hyuck
    Lee, Chang Sup
    [J]. MOLECULES, 2022, 27 (17):
  • [8] ANTI-INFLAMMATORY EFFECTS OF FUCOSTEROL VIA THE SUPPRESSION OF NF-KB PATHWAY AND P38 PATHWAY IN LPS-INDUCED RAW264.7 MACROPHAGE CELLS
    Yoo, M. -S.
    Lee, K. -T.
    [J]. INFLAMMATION RESEARCH, 2011, 60 : 282 - 282
  • [9] Anti-inflammatory role of Leptin in glial cells through p38 MAPK pathway inhibition
    Patraca, Ivan
    Martinez, Nohora
    Busquets, Oriol
    Marti, Aleix
    Pedros, Ignacio
    Beas-Zarate, Carlos
    Marin, Miguel
    Ettcheto, Miren
    Sureda, Francesc
    Auladell, Carme
    Camins, Antoni
    Folch, Jaume
    [J]. PHARMACOLOGICAL REPORTS, 2017, 69 (03) : 409 - 418
  • [10] Solanesol induces the expression of heme oxygenase-1 via p38 and Akt and suppresses the production of proinflammatory cytokines in RAW264.7 cells
    Yao, Xiangyang
    Lu, Binyu
    Lu, Chaotian
    Bai, Qin
    Yan, Dazhong
    Wu, Yanli
    Hong, Zibing
    Xu, Hui
    [J]. FOOD & FUNCTION, 2017, 8 (01) : 132 - 141
12345