Selection of patients with solitary hepatocellular carcinoma for hepatic resection: reassessment of a 5-cm tumor size cut-off

被引:0
|
作者
Jiang, Jing-Hang [1 ]
Zhong, Jian-Hong [2 ]
Zheng, Ming-Hua [4 ]
Cucchetti, Alessandro [5 ]
Luo, Cheng-Piao [3 ]
Gong, Wen-Feng [2 ]
Ma, Liang [2 ]
Xiang, Bang-De [2 ]
Li, Le-Qun [2 ]
Lv, Yang [1 ]
机构
[1] Second Peoples Hosp Jingmen, Dept Gen Surg, Jingmen 448000, Hubei Province, Peoples R China
[2] Guangxi Med Univ, Affiliated Tumor Hosp, Dept Hepatobiliary Surg, Nanning 530021, Peoples R China
[3] Guangxi Med Univ, Affiliated Tumor Hosp, Dept Pathol, Nanning 530021, Peoples R China
[4] Wenzhou Med Univ, Affiliated Hosp 1, Liver Res Ctr, Dept Hepatol, Wenzhou 325000, Peoples R China
[5] Univ Bologna, Alma Mater Studiorum, S Orsola Malpighi Hosp, Dept Med & Surg Sci, I-40138 Bologna, Italy
来源
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2017年 / 10卷 / 04期
关键词
Cut-off point; hepatocellular carcinoma; hepatic resection; overall survival; LONG-TERM SURVIVAL; TERTIARY REFERRAL CENTERS; EASL/AASLD RECOMMENDATIONS; CURATIVE RESECTION; LIVER RESECTION; SNAPSHOT; ADHERENT; OUTCOMES; SURGERY; CANCER;
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
This study compared the efficacy of hepatic resection in patients with solitary hepatocellular carcinoma (HCC) with a tumor diameter > 5 cm or <= 5 cm. A consecutive sample of 386 patients with solitary HCC who were treated by initial resection was divided into those with tumor diameter > 5 cm (n = 203) and those with tumor diameter <= 5 cm (n = 183). A comprehensive literature search of relevant databases was also conducted to assess available evidence on 5 cm as a cut-off point for staging single HCC. Hospital mortality was similar between patients with solitary HCC > 5 cm and those with <= 5 cm, but patients with solitary HCC > 5 cm showed significantly higher morbidity and lower overall survival (both P < 0.05). Meta-analysis of the results of our cohort study with results of 9 studies in the literature (corresponding to 6,008 patients) showed that patients with solitary HCC > 5 cm had significantly worse overall survival than those with <= 5 cm. Therefore, our cohort analysis and literature review suggest that 5 cm is a reliable cut-off point for staging solitary HCC and selecting patients for resection.
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收藏
页码:6283 / 6292
页数:10
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