Cognitive impairment and quality of life in patients with myotonic dystrophy type 1

被引：28
|
作者：
Fujino, Haruo [1 ,2 ]
Shingaki, Honoka [2 ]
Suwazono, Shugo [3 ]
Ueda, Yukihiko [4 ]
Wada, Chizu [5 ]
Nakayama, Takahiro [6 ]
Takahashi, Masanori P. [7 ,8 ]
Imura, Osamu [2 ]
Matsumura, Tsuyoshi [9 ]
机构：
[1] Oita Univ, Dept Special Needs Educ, 700 Dannoharu, Oita 8701192, Japan
[2] Osaka Univ, Grad Sch Human Sci, Osaka, Japan
[3] Natl Hosp Org Okinawa Hosp, Dept Neurol, Ginowan, Okinawa, Japan
[4] Okinawa Int Univ, Ginowan, Okinawa, Japan
[5] Natl Hosp Org Akita Natl Hosp, Dept Neurol, Yurihonjo, Japan
[6] Yokohama Rosai Hosp, Dept Neurol, Yokohama, Kanagawa, Japan
[7] Osaka Univ, Grad Sch Med, Dept Funct Diagnost Sci, Osaka, Japan
[8] Osaka Univ, Grad Sch Med, Dept Neurol, Osaka, Japan
[9] Natl Hosp Org Toneyama Natl Hosp, Dept Neurol, Osaka, Japan
来源：
MUSCLE & NERVE | 2018年 / 57卷 / 05期
关键词：
central nervous system; cognitive deficit; depression; fatigue; myotonic dystrophy type 1; quality of life; FALSE DISCOVERY RATE; JAPANESE VERSION; OUTCOME MEASURES; HEALTH; FATIGUE; DISEASE; SEVERITY; ADULTS; QUESTIONNAIRE; PERSONALITY;
D O I：
10.1002/mus.26022
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
IntroductionThis study sought to clarify whether specific cognitive abilities are impaired in patients with myotonic dystrophy type 1 (DM1) as well as to investigate the relationships among quality of life (QoL), cognitive function, and psychological factors. MethodsSixty patients with DM1 were evaluated on cognitive functioning (abstract reasoning, attention/working memory, executive function, processing speed, and visuoconstructive ability), apathy, depression, excessive daytime sleepiness, fatigue, and QoL. QoL was assessed by 2 domains of the Muscular Dystrophy Quality of Life Scale (Psychosocial Relationships and Physical Functioning and Health). ResultsMore than half of the patients exhibited cognitive impairment in attention/working memory, executive function, processing speed, and visuoconstructive ability. The Psychosocial Relationships factor was associated with processing speed, attention/working memory, and apathy, whereas depression and fatigue were associated with 2 QoL domains. DiscussionOur study identified specific cognitive impairments in DM1. Specific cognitive functions and psychological factors may be potential contributors to QoL. Muscle Nerve57: 742-748, 2018
引用
收藏
页码：742 / 748
页数：7
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