Phomopsidone A, a novel depsidone metabolite from the mangrove endophytic fungus Phomopsis sp A123

被引：32
|
作者：
Zhang, Wei [1 ,2 ]
Xu, Liyan [2 ,3 ]
Yang, Lishan [2 ]
Huang, Yaojian [2 ]
Li, Shengying [1 ]
Shen, Yuemao [4 ]
机构：
[1] Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Shandong Prov Key Lab Energy Genet, Key Lab Biofuels, Qingdao 266101, Shandong, Peoples R China
[2] Xiamen Univ, Sch Life Sci, Xiamen 361005, Fujian, Peoples R China
[3] Putian Univ, Basic Med Coll, Putian 351100, Fujian, Peoples R China
[4] Shandong Univ, Sch Life Sci, Jinan 250100, Shandong, Peoples R China
来源：
FITOTERAPIA | 2014年 / 96卷
关键词：
Depsidones; Isobenzofuranones; Endophyte; Phomopsis; Cytotoxicity; BIOLOGICAL EVALUATION; QUINONE METHIDES; DIARYL ETHERS; ACID; CONSTITUENTS; PACLITAXEL; GENERATION; MECHANISM; PRODUCT; TAXOL;
D O I：
10.1016/j.fitote.2014.05.001
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
One novel pentacyclic depsidone containing an oxetane unit, phomopsidone A (1), together with the reported excelsione (also named as phomopsidone) (2), and four known isobenzofuranones (3-6) were isolated from the mangrove endophytic fungus Phomopsis sp. A123. Their structures were elucidated by 1D and 2D NMR spectroscopic analysis and high resolution mass spectrometry. The bioactivity assays showed that these compounds possess cytotoxic, antioxidant, and antifungal activities. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：146 / 151
页数：6
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