AN IN VIVO INTERMEDIATE FILAMENT ASSEMBLY MODEL

被引：8
|
作者：
Portet, Stephanie [1 ]
Arino, Julien [1 ]
机构：
[1] Univ Manitoba, Dept Math, Winnipeg, MB R3T 2N2, Canada
来源：
MATHEMATICAL BIOSCIENCES AND ENGINEERING | 2009年 / 6卷 / 01期
基金：
加拿大自然科学与工程研究理事会;
关键词：
cytoskeleton assembly dynamics; intermediate filaments; KERATIN-8; PHOSPHORYLATION; NEUROFILAMENT TRANSPORT; EPITHELIAL-CELLS; NETWORKS; VIMENTIN; VITRO; ORGANIZATION; PROTEINS; DYNAMICS; ELEMENTS;
D O I：
10.3934/mbe.2009.6.117
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A model is developed to study the in vivo intermediate filament organization in terms of repartition between four different structural states: soluble proteins, particles, short, and long filaments. An analysis is conducted, showing that the system has a unique, globally asymptotically stable equilibrium. By means of sensitivity analysis, the influence of parameters on the system is studied. It is shown that, in agreement with biological observations, posttranslational modifications of intermediate filament proteins resulting in filament solubilization are the main regulators of the intermediate filament organization. A high signalling-dependent solubilization of filaments favours the intermediate filament aggregation in particles.
引用
收藏
页码：117 / 134
页数：18
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