Metabolite profiles of Stachybotrys isolates from water-damaged buildings and their induction of inflammatory mediators and cytotoxicity in macrophages

被引：46
|
作者：
Nielsen, KF
Huttunen, K
Hyvärinen, A
Andersen, B
Jarvis, BB
Hirvonen, MR
机构：
[1] Tech Univ Denmark, Biocentrum DTU, Mycol Grp, DK-2800 Lyngby, Denmark
[2] Aalborg Univ, Danish Bldg Res Inst, Energy & Indoor Climate Div, DK-2970 Horsholm, Denmark
[3] Natl Publ Hlth Inst, Dept Environm Hlth, FIN-70701 Kuopio, Finland
[4] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA
[5] Univ Maryland, Joint Inst Food Safety & Appl Nutr, College Pk, MD 20742 USA
来源：
MYCOPATHOLOGIA | 2002年 / 154卷 / 04期
关键词：
atranones; satratoxins; mycotoxin; Stachybotrys; inflammation; TNF alpha; IL-6;
D O I：
10.1023/A:1016383402963
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The metabolite profiles of 20 Stachybotrys spp. isolates from Finnish water-damaged buildings were compared with their biological activities. Effects of purified compounds on cytotoxicity and production of inflammatory mediators such as nitric oxide, IL-6 and TNFalpha in murine RAW264.7 macrophage cells were studied. The 11 isolates belonging to the satratoxin-producing chemotype were highly cytotoxic to the macrophages. The isolates inducing inflammatory mediators all belonged to the atranone-producing chemotype, but pure atranones B, and D did not elicit a response in the bioassay. Altogether, cytotoxicity of Stachybotrys sp. isolates appear to be related to satratoxin production whereas the specific component inducing inflammatory responses in atranone-producing isolates remains obscure.
引用
收藏
页码：201 / 205
页数：5
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