RAPH1 in cervical cancer proliferation, migration, and invasion: in vitro studies with SiHa and HeLa cells

被引：0
|
作者：
Chen, H-F [1 ]
Yang, P. [1 ]
Yang, G-Q [1 ]
Lin, Y. [2 ]
Li, J-K [1 ,2 ]
机构：
[1] Sichuan Univ, West China Hosp 2, Dept Gynecol & Obstet, 20,Sec 3,Rerminnan Rd, Chengdu 610041, Sichuan, Peoples R China
[2] Sichuan Univ, Minist Educ, Key Lab Birth Defects & Related Dis Women & Child, Chengdu, Sichuan, Peoples R China
来源：
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY | 2019年 / 40卷 / 02期
基金：
中国国家自然科学基金;
关键词：
RAPH1; Cervical cancer; Cell migration; LAMELLIPODIN; STATISTICS; EXPRESSION;
D O I：
10.12892/ejgo4529.2019
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: Ras association and pleckstrin homology domains 1 (RAPH1) may play a critical role in cervical cancer development, prompting us to investigate its potential role(s) in proliferation, migration, and invasion by cervical cancer cells. Materials and Methods: RAPH1 was knocked down in SiHa and HeLa cervical cancer cells using short interfering RNA. Effects of RAPH1 knock-down were assessed on cell proliferation using the CCK8 assay, and on cell migration and invasion using in vitro transwell assays. Results: Efficient RAPH1 knock-down significant reduced the proliferation, migration, and invasion abilities of SiHa and HeLa cells (p < 0.05). Conclusions: RAPH1 may promote tumor cell proliferation, migration, and invasion during cervical cancer development.
引用
收藏
页码：342 / 344
页数：3
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