Pd(II) complexes with N-substituted pyrazoles as ligands. The influence of the R group [OMe versus NMe2] of [1-{Re(CH2)2-}-3,5-Ph2-(C3HN2)] on their cytotoxic activity on breast cancer cell lines

被引：9

作者：

Chukwu, John U. ^{[1
]}

Lopez, Concepcion ^{[1
]}

Gonzalez, Asensio ^{[2
]}

Font-Bardia, Merce ^{[3
]}

Teresa Calvet, M. ^{[4
]}

Messeguer, Ramon ^{[5
]}

Calvis, Carme ^{[5
]}

机构：

[1] Univ Barcelona, Fac Quim, Dept Quim Inorgan, E-08028 Barcelona, Spain

[2] Univ Barcelona, Fac Farm, Inst Biomed IBUB, Lab Quim Organ, E-08028 Barcelona, Spain

[3] Univ Barcelona, Ctr Cient & Tecnol, Unitat Difraccio Raigs X, E-08028 Barcelona, Spain

[4] Univ Barcelona, Fac Geol, Dept Cristallog Mineral & Diposits Minerals, E-08028 Barcelona, Spain

[5] Parc Cient Barcelona, Leitat Tecnol Ctr, Div Biomed, E-08028 Barcelona, Spain

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2014年 / 766卷

关键词：

Palladium(II) complexes; Cyclopalladation; In vitro studies; Antitumoral activity; Breast cancer; PALLADIUM(II) COMPLEXES; IN-VITRO; STRUCTURAL-CHARACTERIZATION; PLATINUM(II) COMPLEXES; BIOLOGICAL EVALUATION; CRYSTAL-STRUCTURES; PT(II) COMPLEXES; BIOORGANOMETALLIC CHEMISTRY; CYCLOPALLADATED COMPLEXES; ALCOHOL FUNCTIONALITY;

D O I：

10.1016/j.jorganchem.2014.04.034

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The study of the reactivity of the novel pyrazole derivative [1-{MeOe(CH2)(2)-}-3,5-PH2-(C3HN2)] (1) with Na-2[PdCl4] or Pd(OAc)(2) under different experimental conditions has allowed us to isolate and characterize the trans-isomers of [Pd{[1-{MeOe(CH2)(2)-}-3,5-PH2-(C3HN2)]}(2)(X)(2)] [X = Cl (2) or OAc (3)] and the di-m-ligand bridged cyclopalladated complexes [Pd{kappa(2),C,N[1-{MeOe(CH2)(2)-}-3-(C6H4), 5-Ph-(C3HN2)]}(mu-X)](2) [X = OAc (4) or Cl (5)]. Further treatment of compounds 4 or 5 with PPh3 in CH2Cl2 produced the bridge splitting and the formation of [Pd{kappa(2),C,N[1-{MeOe(CH2)(2)-}-3-(C6H4), 5-Ph-(C3HN2)]}X(PPh3)] [X = OAc (6) or Cl (7)]. The cytotoxic assessment of the free ligand (1) and the Pd(II) complexes on the two breast cancer cell lines MCF7 and MDA-MB231 reveals that: a) compound 1 is less active than its analogue [1-{Me2N-(CH2)(2)-}-3,5-Ph(2)e(C3HN2)] (Ic) and b) palladacycles 4-7 showed a remarkable cytotoxic activity in the MDA-MB231 cell line (with IC50 values in the range 9.1-14.4 mu M). (C) 2014 Elsevier B. V. All rights reserved.

引用

页码：13 / 21

页数：9

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