Plasma levels of beta-amyloid (1-42) in Alzheimer's disease and mild cognitive impairment

被引：91

作者：

Pesaresi, Marzia

Lovati, Carlo

Bertora, Pierluigi

Mailland, Enrico

Galimberti, Daniela

Scarpini, Elio

Quadri, Pierluigi

Forloni, Gianluigi ^{[1
]}

Mariani, Claudio

机构：

[1] Ist Ric Farmacol Mario Negri, Dept Neurosci, I-20157 Milan, Italy

[2] Univ Milan, Neurol Unit, Osped Luigi Sacco, Milan, Italy

[3] Osped Maggiore Policlin, Dept Neurol Sci, IRCCS, Milan, Italy

[4] ORBV, Mendrisio, Switzerland

来源：

NEUROBIOLOGY OF AGING | 2006年 / 27卷 / 06期

关键词：

biological markers; protein precursor of amyloid; Apoe; gender; aging;

D O I：

10.1016/j.neurobiolaging.2006.03.004

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

We compared plasma levels of beta-amyloid 1-42 (pg/ml) found for 146 sporadic Alzheimer (AD) patients, 89 subjects with mild cognitive impairment (MCI) and 89 age-matched controls (CT). AD patients had significantly lower levels (38, 54, 52; p < 0.01), unrelated to severity of the disease as assessed by MMSE score, age, sex or APOE4 status. Twenty cases investigated at two time points 18 months apart did not demonstrate further decreases. Thus, the reduction in beta-amyloid 1-42 may be a marker for AD status, specifically, a transition from normal status or MCI to AD, rather than a marker for neurodegenerative processes occurring in the disease. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：904 / 905

页数：2

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