An Efficient Biginelli One-Pot Synthesis of New Benzoxazole-Substituted Dihydropyrimidinones and Thiones Catalysed by Alumina-Supported Trifluoromethane Sulfonic Acid Under Solvent Free Conditions

被引：16
|
作者：
Arjun, M. [2 ]
Sridhar, D. [2 ]
Chari, M. Adharvana [3 ]
Sarangapani, M. [1 ]
机构：
[1] Kakatiya Univ, Dept Chem, Warangal 506009, Andhra Pradesh, India
[2] Kakatiya Univ, Univ Coll Pharmaceut Sci, Warangal 506009, Andhra Pradesh, India
[3] Kyung Hee Univ, Dept Appl Chem, Seoul, South Korea
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2009年 / 46卷 / 01期
关键词：
CALCIUM-CHANNEL BLOCKERS; HIGH-YIELD SYNTHESIS; ANTIHYPERTENSIVE AGENTS; HETEROGENEOUS CATALYST; MICROWAVE IRRADIATION; SILICA; ESTERS; DERIVATIVES; PYRIMIDINES; PROTOCOL;
D O I：
10.1002/jhet.29
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient synthesis of benzoxazole-substituted 3,4-dihydropyrimidinones (DHPMs) using alumina supported trifluoromethane sulfonic acid as the catalyst for the first time from an aldehyde, P-keto ester, and benzoxazole-substituted urea and thiourea under solvent-free conditions is described. When compared with the classical Biginelli reaction conditions, this new method consistently has the advantage of excellent yields (80-93%) and short reaction time (30-120 Minutes) at 120 degrees C temperature.
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页码：119 / 123
页数：5
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