Asymmetric addition of KCN and Ac2O to aldehydes catalyzed by recyclable polymeric salen-Ti(IV) complexes

被引：36

作者：

Huang, W ^{[1
]}

Song, YM ^{[1
]}

Bai, CM ^{[1
]}

Cao, GY ^{[1
]}

Zheng, Z ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 24期

基金：

中国国家自然科学基金;

关键词：

O-acetyl cyanohydrins; recyclable polymeric salen-Ti(IV) complexes; potassium cyanide; aldehyde; asymmetric cyanation;

D O I：

10.1016/j.tetlet.2004.04.086

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Polymeric salen-Ti(IV) complexes were employed in the enantioselective O-acetyl cyanation of aldehydes with KCN and Ac2O. The polymeric catalysts with appropriate crosslinking degree exhibited good activities and enantioselectivities, up to 94% yield and 91% ee were obtained at -20degreesC with 1 mol% of catalyst (based on bimetallic catalytic unit). Moreover, the crosslinked polymeric catalyst could be easily recovered and reused for six consecutive runs without obvious decrease in activity and enantioselectivity. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：4763 / 4767

页数：5