Expression of GLUT4 glucose transporter protein in adipose tissue and skeletal muscle from streptozotocin-induced diabetic pregnant rats

被引:5
|
作者
Yamada, K
Yamakawa, K
Terada, Y
Kawaguchi, K
Sugaya, A
Sugiyama, T
Toyoda, N
机构
[1] Mie Univ, Sch Med, Dept Obstet & Gynecol, Tsu, Mie 5148507, Japan
[2] Mie Univ, Sch Med, Dept Urol, Tsu, Mie 5148507, Japan
关键词
rat; GLUT4; pregnancy; adipose tissue; skeletal muscle; streptozotocin;
D O I
10.1055/s-2007-978785
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Depletion of GLUT4, the primary glucose transporter protein in adipose tissue and skeletal muscle, is reported to contribute to insulin resistance in pregnancy or diabetes. To examine this phenomenon, the expression of GLUT4 protein was assessed by Western blotting in streptozotocin-induced diabetic pregnant rats. In adipose tissue, relative to control, it was decreased by 30% in the normal pregnant group (p < 0.001), by 37% in the diabetic nonpregnant group (p < 0.01) and by 65% in the diabetic pregnant group (p < 0.001). On the other hand, no significant variation was evident among the groups in skeletal muscle. To assess the mechanisms responsible for depletion of GLUT4 protein in adipose tissue, we quantitated levels of GLUT4 mRNA with a RNase protection assay. It was decreased by 44% in the normal pregnant group (p < 0.05) and by 55% in the diabetic pregnant group (p < 0.05), but not altered in the diabetic nonpregnant group. These results suggest that the depletion of GLUT4 protein in adipose tissue is a factor contributing to insulin resistance in pregnancy or diabetes, especially when the two states exist in combination.
引用
收藏
页码:508 / 513
页数:6
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