Sesquiterpenes with hepatoprotective activity from Cnidium monnieri on tacrine-induced cytotoxicity in Hep G2 cells

被引：33
|
作者：
Oh, H
Kim, JS
Song, EK
Cho, H
Kim, DH
Park, SE
Lee, HS
Kim, YC [1 ]
机构：
[1] Wonkwang Univ, MRRC, Iksan 570749, South Korea
[2] Wonkwang Univ, Coll Pharm, Iksan 570749, South Korea
[3] Wonkwang Univ, Profess Grad Sch Oriental Med, Iksan 570749, South Korea
[4] Korea Food & Drug Adm, Seoul, South Korea
来源：
PLANTA MEDICA | 2002年 / 68卷 / 08期
关键词：
D O I：
10.1055/s-2002-33796
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Bioassay-guided fractionation of the EtOH extract of Cnidium monnieri (Apiaceae) furnished two hepatoprotective sesquiter-penes, torilin (1) and torilolone (2), together with a new derivative, 1-hydroxytorilin (3). Compounds 1 and 2 showed hepatoprotective effects on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. The EC50 values of compounds 1 and 2 were 20.6+/-1.86 (P < 0.01) and 3.6+/-0.1 (P < 0.01) muM, respectively. Silybin as a positive control showed an EC50 value of 69.0+/-3.4 muM.
引用
收藏
页码：748 / 749
页数：2
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