CO sniffing through heme-based sensor proteins

被引:18
|
作者
Ascenzi, P
Bocedi, A
Leoni, L
Visca, P
Zennaro, E
Milani, M
Bolognesi, M
机构
[1] Univ Roma Tre, Dept Biol, I-00146 Rome, Italy
[2] Univ Roma Tre, Interdepartmental Lab Electron Microscopy, I-00146 Rome, Italy
[3] Natl Inst Infect Dis, IRCCS Lazzaro Spallanzani, I-00149 Rome, Italy
[4] Univ Aquila, Dept Chem Chem Engn & Mat, I-67100 Laquila, Italy
[5] Ist Giannina Gaslini, I-16147 Genoa, Italy
[6] Univ Genoa, Dept Phys, INFM, I-16146 Genoa, Italy
[7] Univ Genoa, Ctr Excellence Biomed Res, I-16146 Genoa, Italy
[8] Natl Inst Canc Res, Struct Biol Unit, I-16132 Genoa, Italy
关键词
CO sensing; CO signal transduction; CooA; NPAS2;
D O I
10.1080/10258140412331286937
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
O-2, NO, and CO are substrates, products, and/or modulators in many enzymatic reactions including O-2 respiration, denitrification, N-2 fixation, and methanogenesis. Over the last decade, O-2, NO, and CO have been reported to act as signaling molecules in the control of several distinct biological functions. Here, the heme-based mechanisms of CO sensing by the bacterial homodimeric CooA and the mammalian heterodimeric NPAS2-BMAL1 transcriptional factors are reviewed, and the signal transduction pathways are discussed.
引用
收藏
页码:309 / 315
页数:7
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