Effects of hydrogen sulfide on mitochondrial function and cellular bioenergetics

被引：162
|
作者：
Paul, Bindu D. [1 ]
Snyder, Solomon H. [1 ,2 ,3 ]
Kashfi, Khosrow [4 ,5 ]
机构：
[1] Solomon H Snyder Dept Neurosci, Baltimore, MD USA
[2] Dept Psychiat & Behav Sci, Baltimore, MD USA
[3] Johns Hopkins Univ, Dept Pharmacol & Mol Sci, Sch Med, Baltimore, MD 21205 USA
[4] CUNY, Sch Med, Dept Mol Cellular & Biomed Sci, New York, NY 10031 USA
[5] CUNY, Grad Ctr, Grad Program Biol, New York, NY 10016 USA
来源：
REDOX BIOLOGY | 2021年 / 38卷
基金：
美国国家卫生研究院;
关键词：
Mitochondria; Hydrogen sulfide; Sulfide oxidation; Bioenergetics; Cell signaling; Sulfhydration/persulfidation; CYSTATHIONINE-BETA-SYNTHASE; CYTOCHROME-C-OXIDASE; S-SULFHYDRATION; OXIDATIVE-PHOSPHORYLATION; HEART-FAILURE; H2S DONORS; RAT-LIVER; METABOLISM; BIOGENESIS; INHIBITOR;
D O I：
10.1016/j.redox.2020.101772
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hydrogen sulfide (H2S) was once considered to have only toxic properties, until it was discovered to be an endogenous signaling molecule. The effects of H2S are dose dependent, with lower concentrations being beneficial and higher concentrations, cytotoxic. This scenario is especially true for the effects of H2S on mitochondrial function, where higher concentrations of the gasotransmitter inhibit the electron transport chain, and lower concentrations stimulate bioenergetics in multiple ways. Here we review the role of H2S in mitochondrial function and its effects on cellular physiology.
引用
收藏
页数：8
相关论文
共 50 条
  • [31] Hydrogen sulfide and mitochondrial function in Non-Alcoholic Fatty Liver Disease
    Prip-buus, Carina
    EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2019, 49 : 20 - 20
  • [32] Idiopathic Pulmonary Fibrosis: Aging, Mitochondrial Dysfunction, and Cellular Bioenergetics
    Zank, Daniel C.
    Bueno, Marta
    Mora, Ana L.
    Rojas, Mauricio
    FRONTIERS IN MEDICINE, 2018, 5
  • [33] Effects of inhibiting antioxidant pathways on cellular hydrogen sulfide and polysulfide metabolism
    Olson, Kenneth R.
    Gao, Yan
    FREE RADICAL BIOLOGY AND MEDICINE, 2019, 135 : 1 - 14
  • [34] A bioenergetics assay for studying the effects of environmental stressors on mitochondrial function in vivo in zebrafish larvae
    Raftery, Tara D.
    Jayasundara, Nishad
    Di Giulio, Richard T.
    COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, 2017, 192 : 23 - 32
  • [35] Regulation of Mitochondrial Respiration by Hydrogen Sulfide
    Huang, Dandan
    Jing, Guangqin
    Zhu, Shuhua
    ANTIOXIDANTS, 2023, 12 (08)
  • [36] Mechanisms by which hydrogen sulfide attenuates muscle function following ischemia–reperfusion injury: effects on Akt signaling, mitochondrial function, and apoptosis
    Michael D. Wetzel
    Joseph C. Wenke
    Journal of Translational Medicine, 17
  • [37] The influence of inner membrane topology on bioenergetics and mitochondrial function
    Mannella, CA
    JOURNAL OF NEUROCHEMISTRY, 2003, 85 : 56 - 56
  • [38] Mitochondrial function and bioenergetics during malignant transformation and metastasis
    Amoedo, N. D.
    Figueiredo, M. R.
    Jasiulionis, M. G.
    Rumjanek, F. D.
    BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2012, 1817 : S117 - S117
  • [39] Effects of cryopreservation on the mitochondrial bioenergetics of bovine sperm
    Algieri, Cristina
    Blanco-Prieto, Olga
    Llavanera, Marc
    Yeste, Marc
    Spinaci, Marcella
    Mari, Gaetano
    Bucci, Diego
    Nesci, Salvatore
    REPRODUCTION IN DOMESTIC ANIMALS, 2023, 58 (01) : 184 - 188
  • [40] Caffeine and acetaminophen association: Effects on mitochondrial bioenergetics
    Goncalves, Debora F.
    de Carvalho, Nelson R.
    Leite, Martim B.
    Courtes, Aline A.
    Hartmann, Diane D.
    Stefanello, Silvio T.
    da Silva, Ingrid K.
    Franco, Jeferson L.
    Soares, Felix A. A.
    Dalla Corte, Cristiane L.
    LIFE SCIENCES, 2018, 193 : 234 - 241
12345