Effects of hydrogen sulfide on mitochondrial function and cellular bioenergetics

被引：162
|
作者：
Paul, Bindu D. [1 ]
Snyder, Solomon H. [1 ,2 ,3 ]
Kashfi, Khosrow [4 ,5 ]
机构：
[1] Solomon H Snyder Dept Neurosci, Baltimore, MD USA
[2] Dept Psychiat & Behav Sci, Baltimore, MD USA
[3] Johns Hopkins Univ, Dept Pharmacol & Mol Sci, Sch Med, Baltimore, MD 21205 USA
[4] CUNY, Sch Med, Dept Mol Cellular & Biomed Sci, New York, NY 10031 USA
[5] CUNY, Grad Ctr, Grad Program Biol, New York, NY 10016 USA
来源：
REDOX BIOLOGY | 2021年 / 38卷
基金：
美国国家卫生研究院;
关键词：
Mitochondria; Hydrogen sulfide; Sulfide oxidation; Bioenergetics; Cell signaling; Sulfhydration/persulfidation; CYSTATHIONINE-BETA-SYNTHASE; CYTOCHROME-C-OXIDASE; S-SULFHYDRATION; OXIDATIVE-PHOSPHORYLATION; HEART-FAILURE; H2S DONORS; RAT-LIVER; METABOLISM; BIOGENESIS; INHIBITOR;
D O I：
10.1016/j.redox.2020.101772
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hydrogen sulfide (H2S) was once considered to have only toxic properties, until it was discovered to be an endogenous signaling molecule. The effects of H2S are dose dependent, with lower concentrations being beneficial and higher concentrations, cytotoxic. This scenario is especially true for the effects of H2S on mitochondrial function, where higher concentrations of the gasotransmitter inhibit the electron transport chain, and lower concentrations stimulate bioenergetics in multiple ways. Here we review the role of H2S in mitochondrial function and its effects on cellular physiology.
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页数：8
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