Influence of polyunsaturated fatty acids on urologic inflammation

被引：11

作者：

Tamma, Seetha M. ^{[1
]}

Shorter, Barbara ^{[2
,3
]}

Toh, Khai-Lee ^{[4
]}

Moldwin, Robert ^{[5
]}

Gordon, Barbara ^{[6
]}

机构：

[1] Long Isl Univ LIU Post, Dept Biomed Sci & Chair, Sch Hlth Profess & Nursing, Brookville, NY 11548 USA

[2] Long Isl Univ LIU Post, Dept Nutr, Brookville, NY 11548 USA

[3] North Shore LIJ Hlth Syst, Arthur Smith Inst Urol, New Hyde Pk, NY 11042 USA

[4] Mt Elizabeth Med Ctr, Toh Khai Lee Urol Clin, Singapore 228510, Singapore

[5] North Shore LIJ Hlth Syst, Arthur Smith Inst Urol, Hofstra North Shore LIJ Sch Med, Pelv Pain Ctr, New Hyde Pk, NY 11042 USA

[6] Healthcomm Solut, Boise, ID 83703 USA

来源：

INTERNATIONAL UROLOGY AND NEPHROLOGY | 2015年 / 47卷 / 11期

关键词：

Polyunsaturated fatty acids; Omega fatty acids; Bladder; Prostate; Kidney; Inflammation; BLADDER-CANCER-RISK; PROSTATE-CANCER; INTERSTITIAL CYSTITIS; MAST-CELL; OMEGA-3-FATTY-ACIDS; FISH; CALCIUM; CONSUMPTION; OXALATE; DHA;

D O I：

10.1007/s11255-015-1108-8

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Studies demonstrate that polyunsaturated fatty acids, fish oils, and alpha-linoleic acid are beneficial anti-inflammatory agents, which suppress inflammatory mediators and their activity. This review focuses on the effects of omega-3 fatty acids (O-3FAs) on three primary urologic organs (bladder, kidney, and prostate) and associated conditions such as urolithiasis, kidney transplantation, interstitial cystitis/bladder pain syndrome, bladder cancer, prostate cancer (CaP), and chronic prostatitis/chronic pelvic pain syndrome. The following themes emerged: the potential influence of O-3FA in suppressing urologic inflammation; the supportive role of O-3FA in therapeutic interventions; pro-inflammatory mechanisms of omega-6 fatty acids (O-6FAs) associated with disease progression; and the importance of the optimal ratio of O-6FAs/O-3FAs. The need for further research on the role of PUFAs in suppressing urological inflammation precipitated.

引用

页码：1753 / 1761

页数：9

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Barbara Shorter
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Robert Moldwin
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