Generation of a complete thymic microenvironment by MTS24+ thymic epithelial cells

被引：221
|
作者：
Gill, J
Malin, M
Holländer, GA
Boyd, R
机构：
[1] Monash Univ, Sch Med, Dept Pathol & Immunol, Melbourne, Vic 3181, Australia
[2] Univ Basel, Childrens Univ Hosp, Basel, Switzerland
[3] Univ Basel, Dept Clin Biol Sci, Basel, Switzerland
来源：
NATURE IMMUNOLOGY | 2002年 / 3卷 / 07期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1038/ni812
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The epithelial component of the thymic microenvironment is indispensable for the generation of T lymphocytes. Although the heterogeneity of this epithelium is well documented, little is known about precursor-progeny relationships between distinct thymic epithelial lineages. Here we characterized a thymic epithelial cell subpopulation identified by the cell surface glycoprotein MTS24. These cells contained epithelial progenitor cells that were competent and sufficient to fully reconstitute the complex thymic epithelial microenvironment that supported normal T cell development.
引用
收藏
页码：635 / 642
页数：8
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